S-methyl DM1

• Target:

  ADC Cytotoxin|||Microtubule Associated

• Related Pathways:

  Antibody-drug Conjugate/ADC Related|||Cytoskeletal Signaling

• Bioactivity:

  S-methyl DM1, a thiomethyl derivative of Maytansine, binds to tubulin (Kd of 0.93 ?M) and inhibits microtubule polymerization.

• Smiles:

  C[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2OC([C@@H](N(C(CCSC)=O)C)C)=O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H]

• Molecular Formula:

  C36H50ClN3O10S

• Molecular Weight:

  752.31

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  912569-84-7