DM1-SMe

• Target :

  ADC Cytotoxin|||Microtubule Associated

• Related Pathways :

  Cytoskeletal Signaling|||Antibody-drug Conjugate/ADC Related

• Purity :

  0.9961

• Bioactivity :

  DM1-SMe (DM1-SSMe) is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines.

• Smiles :

  [H][C@@]12O[C@@]1(C)[C@H](CC(=O)N(C)c1cc(C\C(C)=C/C=C\[C@@H](OC)[C@@]3(O)C[C@]([H])(OC(=O)N3)[C@H]2C)cc(OC)c1Cl)OC(=O)[C@H](C)N(C)C(=O)CCSSC

• Molecular Formula :

  C36H50ClN3O10S2

• Molecular Weight :

  784.38

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  138148-68-2