DM1-SMe

CAT: 0931-T21408-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T21408-01Size:1 mg
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CAS Number
138148-68-2
Target
ADC Cytotoxin|||Microtubule Associated
Related Pathways
Cytoskeletal Signaling|||Antibody-drug Conjugate/ADC Related
Purity
0.9961
Bioactivity
DM1-SMe (DM1-SSMe) is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines.
Smiles
[H][C@@]12O[C@@]1(C)[C@H](CC(=O)N(C)c1cc(C\C(C)=C/C=C\[C@@H](OC)[C@@]3(O)C[C@]([H])(OC(=O)N3)[C@H]2C)cc(OC)c1Cl)OC(=O)[C@H](C)N(C)C(=O)CCSSC
Molecular Formula
C36H50ClN3O10S2
Molecular Weight
784.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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MBS3615996-01DM1-SMe
HY-100128RDM1-SMe (Standard)
A15960-1DM1-Sme 1mg
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A15960-25DM1-Sme 25mg
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A15960-10DM1-Sme 10mg
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