Midostaurin

• Target :

  PKC|||c-Kit|||VEGFR|||Apoptosis|||NO Synthase

• Related Pathways :

  Cytoskeletal Signaling|||Angiogenesis|||Apoptosis|||Chromatin/Epigenetic|||Immunology/Inflammation|||Tyrosine Kinase/Adaptors

• Purity :

  >99.99%

• Bioactivity :

  PKC412 (Midostaurin (PKC412) ; CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.

• Smiles :

  COC1C(CC2OC1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1

• Molecular Formula :

  C35H30N4O4

• Molecular Weight :

  570.64

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  120685-11-2