SLV-2436

• Description:

  SLV-2436 is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8 nM and 5.4 nM, respectively.

• Product Name Alternative:

  SEL201-88; SEL-201

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  MNK

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/SLV-2436.html

• Purity:

  98.53

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C1C=CC(C2=CC3=C(C=C2)C(N)=NN3)=CN1CC4=CC=CC(Cl)=C4

• Molecular Formula:

  C19H15ClN4O

• Molecular Weight:

  350.80

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Zhan Y, et al. MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma. J Clin Invest. 2017 Nov 1;127 (11) :4179-4192.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MNK1; MNK2

• CAS Number:

  2095704-43-9