MMAF-OMe

CAT: 0931-MF-0020582-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0020582-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
863971-12-4
Target
ADC Cytotoxin
Related Pathways
Antibody-drug Conjugate/ADC Related
Purity
0.9934
Bioactivity
MMAF-OMe (Monomethyl auristatin F methyl ester) is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. MMAF-Ome is also an ADC cytotoxin.
Smiles
CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC)OC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C
Molecular Formula
C40H67N5O8
Molecular Weight
745.99
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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