LS-102

CAT: 0931-T11879-08Size: 200 mgDry Ice: NoHazardous: No

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CAT#:0931-T11879-08Size:200 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1456891-34-1

Target

Ligand for E3 Ligase, E1/E2/E3 Enzyme

Related Pathways

Ubiquitination, PROTAC

Purity

0.9892

Bioactivity

LS-102 is a selective inhibitor of the E3 ligase synoviolin (Syvn1), an astragaloside IV derivative, which attenuates myocardial ischemia/reperfusion injury by inhibiting mitochondrial fission.LS-102 inhibits Syvn1 auto-ubiquitylation, which ameliorates amyloidazole-induced slowing of the heart rate, and is useful for studying cardiovascular diseases.

Smiles

CCNCCN(CC)c1nc(N[C@@H](C)C2CCCCC2)nc(Nc2ccc3ncoc3c2)n1

Molecular Formula

C24H36N8O

Molecular Weight

452.6

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

(S)-N2-(Benzo[d]oxazol-6-yl)-N4-(1-cyclohexylethyl)-N6-ethyl-N6-(2-(ethylamino)ethyl)-1,3,5-triazine-2,4,6-triamine

CAS Number	1456891-34-1
PubChem CID	118518043
IUPAC Name	6-N-(1,3-benzoxazol-6-yl)-4-N-[(1S)-1-cyclohexylethyl]-2-N-ethyl-2-N-[2-(ethylamino)ethyl]-1,3,5-triazine-2,4,6-triamine
Molecular Formula	C24H36N8O
Molecular Weight	452.6
XLogP	5.6
Topological Polar Surface Area	104
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	11
Heavy Atom Count	33
Formal Charge	0
Complexity	563

SMILES

CCNCCN(CC)C1=NC(=NC(=N1)N[C@@H](C)C2CCCCC2)NC3=CC4=C(C=C3)N=CO4

InChI

InChI=1S/C24H36N8O/c1-4-25-13-14-32(5-2)24-30-22(27-17(3)18-9-7-6-8-10-18)29-23(31-24)28-19-11-12-20-21(15-19)33-16-26-20/h11-12,15-18,25H,4-10,13-14H2,1-3H3,(H2,27,28,29,30,31)/t17-/m0/s1

InChIKey

DEDHMXBDEJSZFE-KRWDZBQOSA-N

Chemical Structure

2D Structure

CAS: 1456891-34-1

CID: 118518043

Formula: C24H36N8O

MW: 452.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	452.6
XLogP3	5.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	11
Exact Mass	452.30120780
Monoisotopic Mass	452.30120780
Topological Polar Surface Area	104 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	563
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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LS-102

Chemical Information

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