LS-106

CAT: 0013-GTR19237513-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19237513-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

LS-106 is a potent, orally bioavailable EGFR inhibitor effective against C797S triple-mutant variants, including EGFR19del/T790M/C797S (IC50=2.4 nM) . It demonstrates superior in vitro kinase inhibition compared to Osimertinib, induces apoptosis, and shows significant in vivo antitumor efficacy in xenograft models harboring these resistant mutations.

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Molecular Formula

C24H28BrClN5OP

Molecular Weight

548.84

Storage Conditions

-20°C

Notes

For research use only.

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