Duocarmycin SA

• Target:

  DNA Alkylator/Crosslinker|||Apoptosis|||Necroptosis|||ADC Cytotoxin|||Antibiotic

• Related Pathways:

  DNA Damage/DNA Repair|||Antibody-drug Conjugate/ADC Related|||Apoptosis|||Microbiology/Virology

• Bioactivity:

  Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro.

• Smiles:

  C(=O)(N1C=2[C@]3([C@](C3)(C1)[H])C4=C(NC(C(OC)=O)=C4)C(=O)C2)C=5NC=6C(C5)=CC(OC)=C(OC)C6OC

• Molecular Formula:

  C25H23N3O7

• Molecular Weight:

  477.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  130288-24-3