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Duocarmycin SA

CAT: 0931-T11118-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0931-T11118-01Size:100 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
130288-24-3
Target
DNA Alkylator/Crosslinker|||Apoptosis|||Necroptosis|||ADC Cytotoxin|||Antibiotic
Related Pathways
DNA Damage/DNA Repair|||Antibody-drug Conjugate/ADC Related|||Apoptosis|||Microbiology/Virology
Bioactivity
Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro.
Smiles
C(=O)(N1C=2[C@]3([C@](C3)(C1)[H])C4=C(NC(C(OC)=O)=C4)C(=O)C2)C=5NC=6C(C5)=CC(OC)=C(OC)C6OC
Molecular Formula
C25H23N3O7
Molecular Weight
477.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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