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Duocarmycin A

CAT: 0931-T15180-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0931-T15180-01Size:100 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
118292-34-5
Target
Apoptosis|||Caspase|||ADC Cytotoxin
Related Pathways
Antibody-drug Conjugate/ADC Related|||Proteases/Proteasome|||Apoptosis
Bioactivity
Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3? end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.
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O=C1C=2[C@]34[C@](C3)(CN(C(=O)C=5NC=6C(C5)=CC(OC)=C(OC)C6OC)C4=CC(=O)C2N[C@]1(C(OC)=O)C)[H]
Molecular Formula
C26H25N3O8
Molecular Weight
507.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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