Duocarmycin A

• Target:

  Apoptosis|||Caspase|||ADC Cytotoxin

• Related Pathways:

  Antibody-drug Conjugate/ADC Related|||Proteases/Proteasome|||Apoptosis

• Bioactivity:

  Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3? end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.

• Smiles:

  O=C1C=2[C@]34[C@](C3)(CN(C(=O)C=5NC=6C(C5)=CC(OC)=C(OC)C6OC)C4=CC(=O)C2N[C@]1(C(OC)=O)C)[H]

• Molecular Formula:

  C26H25N3O8

• Molecular Weight:

  507.49

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  118292-34-5