DM4-SMe

CAT: 0931-T11059-01Size: 25 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0931-T11059-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

CAS Number

796073-68-2

Target

Microtubule Associated, ADC Cytotoxin

Related Pathways

Cytoskeletal Signaling, Antibody-drug Conjugate/ADC Related

Bioactivity

DM4-SMe is a cytotoxic part of antibody-drug conjugates (ADCs) and a metabolite of antibody-maytansin conjugates (AMCs) and tubulin inhibitors, which can also be stabilized by disulfide bonds or thioether The bond binds to the antibody. The IC50 of DM4-SMe on KB cells was 0.026 nM.

Smiles

[H][C@@]12C[C@@](O)(NC(=O)O1)[C@]([H])(OC)\C=C/C=C(C)\Cc1cc(OC)c(Cl)c(c1)N(C)C(=O)C[C@]([H])(OC(=O)[C@H](C)N(C)C(=O)CCC(C)(C)SSC)[C@]1(C)O[C@H]1[C@@H]2C

Molecular Formula

C39H56ClN3O10S2

Molecular Weight

826.46

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Related Products

Catalog	Name
T11057	DM3-SMe
T21408-01	DM1-SMe
T15141-01	DM4
T89651-01	DM4-d6
T17833-01	DM4-SMCC
T13766	Maytansinoid DM4
T17834-01	DM4-SPDP
T18702-01	DBA-DM4
T18701-01	SPDB-DM4
T75100-01	DM-CO- (CH2) 5-SMe

Alternative Products

Catalog	Name
WGB07368-01	DM4-SMe
BA2343-50	DM1-SMe
WGB07370-01	DM3-SMe
GTR17970734	SmE Antibody
A15960-100	DM1-Sme 100mg
A15960-25	DM1-Sme 25mg
A15960-5	DM1-Sme 5mg
A15960-1	DM1-Sme 1mg
HY-100128R	DM1-SMe (Standard)

DM4-SMe

Related Products

Alternative Products

Popular Products