DM4-SMe

• Target :

  Microtubule Associated|||ADC Cytotoxin

• Related Pathways :

  Cytoskeletal Signaling|||Antibody-drug Conjugate/ADC Related

• Bioactivity :

  DM4-SMe is a cytotoxic part of antibody-drug conjugates (ADCs) and a metabolite of antibody-maytansin conjugates (AMCs) and tubulin inhibitors, which can also be stabilized by disulfide bonds or thioether The bond binds to the antibody. The IC50 of DM4-SMe on KB cells was 0.026 nM.

• Smiles :

  [H][C@@]12C[C@@](O)(NC(=O)O1)[C@]([H])(OC)\C=C/C=C(C)\Cc1cc(OC)c(Cl)c(c1)N(C)C(=O)C[C@]([H])(OC(=O)[C@H](C)N(C)C(=O)CCC(C)(C)SSC)[C@]1(C)O[C@H]1[C@@H]2C

• Molecular Formula :

  C39H56ClN3O10S2

• Molecular Weight :

  826.46

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  796073-68-2