DM4-SMe

• Target:

  Microtubule Associated|||ADC Cytotoxin

• Related Pathways:

  Cytoskeletal Signaling|||Antibody-drug Conjugate/ADC Related

• Bioactivity:

  DM4-SMe is a cytotoxic part of antibody-drug conjugates (ADCs) and a metabolite of antibody-maytansin conjugates (AMCs) and tubulin inhibitors, which can also be stabilized by disulfide bonds or thioether The bond binds to the antibody. The IC50 of DM4-SMe on KB cells was 0.026 nM.

• Smiles:

  [H][C@@]12C[C@@] (O) (NC (=O) O1) [C@] ([H]) (OC) \C=C/C=C (C) \Cc1cc (OC) c (Cl) c (c1) N (C) C (=O) C[C@] ([H]) (OC (=O) [C@H] (C) N (C) C (=O) CCC (C) (C) SSC) [C@]1 (C) O[C@H]1[C@@H]2C

• Molecular Formula:

  C39H56ClN3O10S2

• Molecular Weight:

  826.46

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  796073-68-2