CSRM617 hydrochloride

• Target :

  Apoptosis|||Androgen Receptor

• Related Pathways :

  Apoptosis|||Endocrinology/Hormones

• Purity :

  0.9959

• Bioactivity :

  CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor), with a Kd of 7.43 µM in SPR assays, directly binding to the OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP and is well tolerated in the mouse model of prostate cancer [1].

• Smiles :

  Cl.NC(CO)C(=O)N\N=C\c1ccc(O)c(O)c1O

• Molecular Formula :

  C10H14ClN3O5

• Molecular Weight :

  291.69

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1353749-74-2