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CSRM617 hydrochloride

CAT: 0931-T10896L-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T10896L-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1353749-74-2
Target
Apoptosis, Androgen Receptor
Related Pathways
Apoptosis, Endocrinology/Hormones
Purity
0.9959
Bioactivity
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor), with a Kd of 7.43 μM in SPR assays, directly binding to the OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP and is well tolerated in the mouse model of prostate cancer [1].
Smiles
Cl.NC(CO)C(=O)N\N=C\c1ccc(O)c(O)c1O
Molecular Formula
C10H14ClN3O5
Molecular Weight
291.69
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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