CSRM617 hydrochloride

• Target:

  Apoptosis|||Androgen Receptor

• Related Pathways:

  Apoptosis|||Endocrinology/Hormones

• Purity:

  0.9959

• Bioactivity:

  CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor), with a Kd of 7.43 µM in SPR assays, directly binding to the OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP and is well tolerated in the mouse model of prostate cancer [1].

• Smiles:

  Cl.NC (CO) C (=O) N\N=C\c1ccc (O) c (O) c1O

• Molecular Formula:

  C10H14ClN3O5

• Molecular Weight:

  291.69

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1353749-74-2