AZ-3

CAT: 0931-T10424-01Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0931-T10424-01Size:100 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2228908-91-4

Target

JAK

Related Pathways

Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, JAK/STAT signaling, Angiogenesis, Stem Cells

Bioactivity

AZ-3 is a potent and selective JAK1 inhibitor (IC50: 34 nM) .

Smiles

CN1C[C@]2(N(C[C@@]1(C2)[H])C=3C=C(NC=4N=C(N[C@@H](CC)C)C(C)=CN4)C(F)=NC3)[H]

Molecular Formula

C20H28FN7

Molecular Weight

385.48

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

4-N-[(2R)-butan-2-yl]-2-N-[2-fluoro-5-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-3-pyridinyl]-5-methylpyrimidine-2,4-diamine

CAS Number	2228908-91-4
PubChem CID	138319690
IUPAC Name	4-N-[(2R)-butan-2-yl]-2-N-[2-fluoro-5-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-3-pyridinyl]-5-methylpyrimidine-2,4-diamine
Molecular Formula	C20H28FN7
Molecular Weight	385.5
XLogP	3.6
Topological Polar Surface Area	69.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	6
Heavy Atom Count	28
Formal Charge	0
Complexity	523

SMILES

CC[C@@H](C)NC1=NC(=NC=C1C)NC2=C(N=CC(=C2)N3C[C@@H]4C[C@H]3CN4C)F

InChI

InChI=1S/C20H28FN7/c1-5-13(3)24-19-12(2)8-23-20(26-19)25-17-7-14(9-22-18(17)21)28-11-15-6-16(28)10-27(15)4/h7-9,13,15-16H,5-6,10-11H2,1-4H3,(H2,23,24,25,26)/t13-,15+,16+/m1/s1

InChIKey

UPSHDXGMMFOWPL-KBMXLJTQSA-N

Chemical Structure

2D Structure

CAS: 2228908-91-4

CID: 138319690

Formula: C20H28FN7

MW: 385.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	385.5
XLogP3	3.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	6
Exact Mass	385.23902208
Monoisotopic Mass	385.23902208
Topological Polar Surface Area	69.2 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	523
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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T209551-01	AZ'9567
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Alternative Products

Catalog	Name
HY-112442	AZ-3
A19217-10	AZ-3 10mg
A19217-5	AZ-3 5mg
A19217-100	AZ-3 100mg
A19217-25	AZ-3 25mg
A19217-1	AZ-3 1mg
A19217-50	AZ-3 50mg
B7362-50	AZ 11645373
A4144-50	AZ 960
BA5741-1	AZ-1355

AZ-3

Chemical Information

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