AKT-IN-3

CAT: 0931-T10275-01Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0931-T10275-01Size:100 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2374740-21-1

Target

Apoptosis, Akt

Related Pathways

PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Apoptosis

Bioactivity

AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3) . AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK.

Smiles

CNC(=O)C[C@@H]1C[C@H]([C@@H](CN1)NC(=O)c1cc(c(Cl)o1)-c1c(Cl)cnn1C)c1ccc(F)c(F)c1

Molecular Formula

C23H23Cl2F2N5O3

Molecular Weight

526.36

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
HY-126257-01	AKT-IN-3
HY-161816	PI3K/AKT-IN-3
HY-147913	PI3K/Akt/mTOR-IN-3
MBS621504-01	AKT 1/2/3
519967-01	Akt
SF2784-10mM	AKT inhibitor VIII (Akt inhibitor)
YP-W21449-01	Mouse AKT (AKT) ELISA Kit

AKT-IN-3

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