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AKT-IN-28

CAT: 0931-T210579-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210579-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Apoptosis, PARP, Caspase, Akt, Wnt/beta-catenin
Related Pathways
PI3K/Akt/mTOR signaling, Chromatin/Epigenetic, Stem Cells, Apoptosis, DNA Damage/DNA Repair, Proteases/Proteasome, Cytoskeletal Signaling
Bioactivity
AKT-IN-28 is an allosteric inhibitor of Akt and a derivative of Shikonin. It effectively binds to Akt's allosteric site through hydrophobic and hydrogen bond interactions, with a Kd value of 2.07 μM. AKT-IN-28 significantly inhibits Akt activity, inducing apoptosis in KRAS-mutant colorectal cancer cells, arresting the cell cycle at the G2/M phase, and suppressing cell proliferation, migration, and metabolism.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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