AAPK-25

• Target:

  Apoptosis|||Aurora Kinase|||PLK

• Related Pathways:

  Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||Apoptosis

• Purity:

  0.9779

• Bioactivity:

  AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, causing mitotic delay and arresting cells in prometaphase, followed by increased apoptosis. It targets Aurora-A/-B/-C with Kd values ranging from 23-289 nM.

• Smiles:

  Clc1ccc(cc1Cl)C(=O)Nc1ccc2cc(ccc2c1)C(=O)Nc1nccs1

• Molecular Formula:

  C21H13Cl2N3O2S

• Molecular Weight:

  442.32

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2247919-28-2