GSK-25

• Target:

  MTOR|||ROCK|||S6 Kinase

• Related Pathways:

  Stem Cells|||Cell Cycle/Checkpoint|||PI3K/Akt/mTOR signaling|||Cytoskeletal Signaling|||MAPK

• Purity:

  0.9914

• Bioactivity:

  GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested) .

• Smiles:

  CC1=C(C(N=C(N1)c1ccnc(Cl)c1)c1ccc(Cl)cc1F)C(=O)Nc1cc2cn[nH]c2cc1F

• Molecular Formula:

  C24H16Cl2F2N6O

• Molecular Weight:

  513.33

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  874119-56-9