Hydroxy-Dynasore

Hydroxy-Dynasore

• CAS Number: 1256493-34-1
• UNSPSC Description: Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore (HY-15304), is an improved, less cytotoxic and versatile dynamin inhibitor with IC50 values ​​of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC50 of 5.7 μM.
• Target Antigen: Dynamin
• Type: Reference compound
• Related Pathways: Cytoskeleton
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/hydroxy-dynasore.html
• Smiles: OC1=CC2=CC=CC=C2C=C1C(N/N=C/C3=C(O)C=C(O)C(O)=C3)=O
• Molecular Weight: 338.31
• References & Citations: [1]Adam McCluskey, et al. Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis. Traffic. 2013 Dec;14(12):1272-89.|[2]Callista B Harper, et al.Dynamin Inhibition Blocks Botulinum Neurotoxin Type A Endocytosis in Neurons and Delays Botulism.J Biol Chem. 2011 Oct 14;286(41):35966-76.
• Shipping Conditions: Room Temperature