Hydroxy-Dynasore

• Description :

  Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore (HY-15304), is an improved, less cytotoxic and versatile dynamin inhibitor with IC50 values ​​of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC50 of 5.7 μM.

• Product Name Alternative :

  Dyngo-4a

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H332

• Target :

  Dynamin

• Type :

  Reference compound

• Related Pathways :

  Cytoskeleton

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/hydroxy-dynasore.html

• Purity :

  99.11

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  OC1=CC2=CC=CC=C2C=C1C(N/N=C/C3=C(O)C=C(O)C(O)=C3)=O

• Molecular Formula :

  C18H14N2O5

• Molecular Weight :

  338.31

• Precautions :

  H302, H312, H332

• References & Citations :

  [1]Adam McCluskey, et al. Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis. Traffic. 2013 Dec;14 (12) :1272-89.|[2]Callista B Harper, et al.Dynamin Inhibition Blocks Botulinum Neurotoxin Type A Endocytosis in Neurons and Delays Botulism.J Biol Chem. 2011 Oct 14;286 (41) :35966-76.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1256493-34-1]