Hydroxy-Dynasore

• UNSPSC Description:

  Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore (HY-15304), is an improved, less cytotoxic and versatile dynamin inhibitor with IC50 values ​​of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC50 of 5.7 μM.

• Target Antigen:

  Dynamin

• Type:

  Reference compound

• Related Pathways:

  Cytoskeleton

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/hydroxy-dynasore.html

• Smiles:

  OC1=CC2=CC=CC=C2C=C1C(N/N=C/C3=C(O)C=C(O)C(O)=C3)=O

• Molecular Weight:

  338.31

• References & Citations:

  [1]Adam McCluskey, et al. Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis. Traffic. 2013 Dec;14(12):1272-89.|[2]Callista B Harper, et al.Dynamin Inhibition Blocks Botulinum Neurotoxin Type A Endocytosis in Neurons and Delays Botulism.J Biol Chem. 2011 Oct 14;286(41):35966-76.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  1256493-34-1