Dynasore

• Description :

  Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 μM. Dynasore blocks cell migration.

• UNSPSC :

  12352005

• Hazard Statement :

  H302+H312, H315, H318, H411

• Target :

  Autophagy; Dynamin; HSV; Virus Protease

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Autophagy; Cytoskeleton

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/Dynasore.html

• Purity :

  99.66

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C(O)C=C2C=CC=CC2=C1)N/N=C/C3=CC=C(O)C(O)=C3

• Molecular Formula :

  C18H14N2O4

• Molecular Weight :

  322.31

• Precautions :

  H302+H312, H315, H318, H411

• References & Citations :

  [1]Macia E, et al. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006 Jun;10 (6) :839-50.|[2]Mues MB, et al. Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol. 2015 Jul;89 (13) :6673-84.|[3]Gao D, et al. Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. PLoS One. 2013 Apr 15;8 (4) :e60967.|[4]Li G, et al. Dynasore Improves Motor Function Recovery via Inhibition of Neuronal Apoptosis and Astrocytic Proliferation after Spinal Cord Injury in Rats. Mol Neurobiol. 2016 Nov 7.|[5]Liang Ma, et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015 Jan;25 (1) :24-38.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HSV-1; HSV-2

• Citation 01 :

  AAPS PharmSciTech. 2023 Feb 15;24 (2) :69.|Adv Funct Mater. 2023 Jan 15.|Adv Funct Mater. 2024 May 1.|Adv Healthc Mater. 2024 Jul 16:e2401460.|Adv Mater. 2022 Jul 28; e2204287.|Adv Mater. 2025 Jan 10:e2415030.|Adv Sci (Weinh) . 2023 Feb;10 (4) :e2204871.|Adv Sci (Weinh) . 2025 Sep 3:e02788.|Alzheimers Dement. 2025 Aug;21 (8) :e70331.|Anal Chem. 2020 Jan 21;92 (2) :2103-2111.|Antioxidants (Basel) . 2022 Nov 22;11 (12) :2307.|Arab J Chem. 2020, 13 (1) : 2558-2567.|Autophagy. 2025 May 31:1-21.|Biol Res. 2023 Mar 11;56 (1) :10.|Biomaterials. 2022 May;284:121529.|bioRxiv. 2025 Jul 29.|bioRxiv. 2025 Oct 24.|Cancer Immunol Res. 2022 Jul 1;10 (7) :844-855.|Cell Commun Signal. 2020 Nov 4;18 (1) :176.|Cell Death Differ. 2024 Nov;31 (11) :1519-1533.|Cell Host Microbe. 2025 Sep 30:S1931-3128 (25) 00375-0.|Cell Rep. 2022 Jun 14;39 (11) :110943.|Comput Struct Biotechnol J. 2021;19:1933-1943.|Drug Deliv. 2018 Nov;25 (1) :1066-1079. |EBioMedicine. 2022 Aug:82:104181.|Elife. 2022 Jun 28;11:e78044.|EMBO Rep. 2025 Sep 15.|Environ Health. 2025 Nov 6.|Environ Sci Technol. 2023 Jun 13;57 (23) :8514-8523.|Eur J Cell Biol. 2019 Jan;98 (1) :36-50.|Eur J Pharmacol. 2021 Sep 15:907:174203.|FEBS J. 2025 Mar;292 (5) :1052-1069.|Food Chem. 2024 Sep 8;463 (Pt 1) :141196.|Front Cell Dev Biol. 2021 Jul 7;9:687322.|Genes Dis. 2025 Aug 14.|Immunity. 2025 Jun 10;58 (6) :1469-1483.e8.|Int Immunopharmacol. 2025 Sep 23:162:115167.|Int J Biol Macromol. 2022 Aug 31:215:23-35.|Int J Biol Sci. 2024 Sep 3;20 (12) :4713-4730.|Int J Mol Sci. 2025 Mar 29;26 (7) :3172.|Int J Pharm. 2024 Apr 25:655:124072.|J Am Chem Soc. 2018 Dec 12;140 (49) :17234-17240.|J Cancer. 2025 Jan 27;16 (5) :1466-1478. |J Extracell Vesicles. 2021 Jul;10 (9) :e12117.|J Extracell Vesicles. 2025 Aug;14 (8) :e70146.|J Hazard Mater. 2021 Sep 5;417:126092.|J Virol. 2021 Nov 23;95 (24) :e0134521.|J Virol. 2025 Aug 25:e0022125.|Mov Disord. 2024 Jan;39 (1) :40-52.|Nano Lett. 2019 Nov 13;19 (11) :8010-8020. |Nat Commun. 2021 Jun 9;12 (1) :3481.|Nat Commun. 2025 Aug 27;16 (1) :7994.|Nat Commun. 2025 Nov 13;16 (1) :9973.|Nat Nanotechnol. 2020 Dec;15 (12) :1043-1052.|Nat Plants. 2025 Sep 12.|Neurotox Res. 2019 Jul;36 (1) :108-116.|Oncogene. 2018 Jan 4;37 (1) :116-127. |Plant Biotechnol J. 2025 Aug;23 (8) :3237-3253.|PLoS Pathog. 2021 Jul 21;17 (7) :e1009752.|Redox Biol. 2022 Apr;50:102257.|Redox Biol. 2025 May:82:103581.|Research Square Preprint. 2021 Aug.|Research Square Preprint. 2023 Apr 19.|Research Square Preprint. 2023 Aug 7.|Research Square Print. 2022 May.|Sci Bull. 2020 Nov 15;65 (21) :1796-1799.|Sci China Life Sci. 2022 Feb;65 (2) :341-361.|Sci Rep. 2023 May 25;13 (1) :8479.|Signal Transduct Target Ther. 2024 Sep 26;9 (1) :254.|Small Methods. 2021 Apr;5 (4) :e2001047.|SSRN. 14 Feb 2022.|SSRN. 2023 Sep 15.|SSRN. 2025 Sep 30.|Toxins. 2023 Feb 6;15 (2) :132.|Virology. 2024 Dec:600:110233.|Virus Res. 2020 Jan 15;276:197806.|J Autoimmun. 2023 Apr:136:103012.

• CAS Number :

  [304448-55-3]