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ESX1 rabbit pAb

CAT: 0855-ES16662-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES16662-01Size:50 µL
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Background
This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010]
Description
This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010],
UniProt
Q8N693
Swiss Prot
Q8N693
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human ESX1 AA range: 327-377
Target
ESX1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
Gene ID (Human)
80712

UniProtKB · Q8N693

Homeobox protein ESX1

ESX1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8N693
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ESX1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B0QYU3, Q7Z6K7
Protein keywords

Cellular component

CytoplasmNucleus

Molecular function

DNA-bindingRepressor

Domain

HomeoboxRepeat

Technical term

Proteomics identificationReference proteome

Biological process

TranscriptionTranscription regulation

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