(Rac) -AAA

• Description:

  (Rac) -AAA is the racemate of AAA. (Rac) -AAA is an antagonist of 20-HETE receptor. (Rac) -AAA can increase the expression of GPR75 receptor in androgen-insensitive prostate cancer cells. (Rac) -AAA dose-dependently increases p38 phosphorylation. (Rac) -AAA induces a significant decrease in the phosphor-AKT signal in nuclei of cells. (Rac) -AAA mitigates the NF-κB signal in unstimulated cell nuclei. (Rac) -AAA can diminish the membrane associated signal intensity. (Rac) -AAA decreases the FAK phosphorylation induced by 20-HETE[1].

• UNSPSC:

  12352211

• Target:

  Cytochrome P450; FAK; Orphan GPCR; p38 MAPK

• Related Pathways:

  GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Smiles:

  O=C (C (NC (CCCC/C=C\CCCCCCC/C=C\CCCCO) =O) CC (O[Na]) =O) O[Na]

• Molecular Formula:

  C24H39NNa2O6

• Molecular Weight:

  483.55

• References & Citations:

  [1]Cárdenas, S., et al., (2020) . GPR75 receptor mediates 20-HETE-signaling and metastatic features of androgen-insensitive prostate cancer cells. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865 (2), 158573.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3055022-23-3