(Rac) -AAA

• Description :

  (Rac) -AAA is the racemate of AAA. (Rac) -AAA is an antagonist of 20-HETE receptor. (Rac) -AAA can increase the expression of GPR75 receptor in androgen-insensitive prostate cancer cells. (Rac) -AAA dose-dependently increases p38 phosphorylation. (Rac) -AAA induces a significant decrease in the phosphor-AKT signal in nuclei of cells. (Rac) -AAA mitigates the NF-κB signal in unstimulated cell nuclei. (Rac) -AAA can diminish the membrane associated signal intensity. (Rac) -AAA decreases the FAK phosphorylation induced by 20-HETE[1].

• UNSPSC :

  12352211

• Target :

  Cytochrome P450; FAK; Orphan GPCR; p38 MAPK

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Smiles :

  O=C(C(NC(CCCC/C=C\CCCCCCC/C=C\CCCCO)=O)CC(O[Na])=O)O[Na]

• Molecular Formula :

  C24H39NNa2O6

• Molecular Weight :

  483.55

• References & Citations :

  [1]Cárdenas, S., et al., (2020) . GPR75 receptor mediates 20-HETE-signaling and metastatic features of androgen-insensitive prostate cancer cells. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865 (2), 158573.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3055022-23-3]