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(Rac) -AAA

CAT: 0804-HY-160187A-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-160187A-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(Rac) -AAA is the racemate of AAA. (Rac) -AAA is an antagonist of 20-HETE receptor. (Rac) -AAA can increase the expression of GPR75 receptor in androgen-insensitive prostate cancer cells. (Rac) -AAA dose-dependently increases p38 phosphorylation. (Rac) -AAA induces a significant decrease in the phosphor-AKT signal in nuclei of cells. (Rac) -AAA mitigates the NF-κB signal in unstimulated cell nuclei. (Rac) -AAA can diminish the membrane associated signal intensity. (Rac) -AAA decreases the FAK phosphorylation induced by 20-HETE[1].
CAS Number
3055022-23-3
UNSPSC
12352211
Target
Cytochrome P450; FAK; Orphan GPCR; p38 MAPK
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(C(NC(CCCC/C=C\CCCCCCC/C=C\CCCCO)=O)CC(O[Na])=O)O[Na]
Molecular Formula
C24H39NNa2O6
Molecular Weight
483.55
References & Citations
[1]Cárdenas, S., et al., (2020) . GPR75 receptor mediates 20-HETE-signaling and metastatic features of androgen-insensitive prostate cancer cells. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865 (2), 158573.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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