PF-06463922

CAT: 0026-B1169-10Size: 10 mgDry Ice: NoHazardous: No
CAT#:0026-B1169-10Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-06463922 is a potent, selective, brain-penetrant, and high affinity ALK (Anaplastic lymphoma kinase) and ROS1 (c-Ros oncogene 1) inhibitor displaying >100-fold selectivity for ROS1 over panel of 204 other kinases. It has strong activity against all known ALK and ROS1 mutants identified in patients, including the EML4-L1196M mutant of ALK (Ki = < 0.02 nM). It inhibits proliferation of BaF3 cells containing Crizotinib resistant ROS1 mutation in vitro.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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