Products for Research Use Only

FTI-277 hydrochloride

CAT: 0026-2874-5Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0026-2874-5Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
FTI-277 is a potent and selective farnesyltransferase (FTase) inhibitor (IC50 = 0.5 nM). It potently inhibits (IC₅₀ = 100 nM) H-Ras, but not the geranylgeranylated Rap1A processing in whole cells. FTI-277 blocks constitutive activation of mitogen-activated protein kinase (MAPK) in H-RasF, but not H-RasGG, or Raf-transformed cells.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months