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Smo Antagonist, SA1

CAT: 0026-2154-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-2154-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 3.1 µM). Also inhibits the localization of Smo to cilia. Treatment of Ptch1-/- MEFs with SA1 suppresses the β-galactosidase activity (IC₅₀ = 3.8 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
24months

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