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QuickDetect™ 24 (S)-Hydroxycholesterol (Human) ELISA Kit

CAT: 0026-K4434-100Size: 100 AssaysDry Ice: NoHazardous: No
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CAT#:0026-K4434-100Size:100 Assays
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
An important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain. It is an endogenous agonist of the nuclear receptor LXR. It has been shown to induce cell death in neuroblastoma cells, possibly via a necroptosis pathway. 24(S)-Hydroxycholesterol has also been found to be a high affinity ligand for RORα and RORγ (Ki = 25 nM). 24(S)-Hydroxycholesterol levels are elevated in the cerebral spinal fluids of patients with neurogenerative diseases suggesting possible clinical applications. It was also able to reduce Aβ production and increase ER-resident immature amyloid precursor protein (APP) levels in human neuroblastoma SH-Sy5Y cells and CHO cells via inhibition of intracellular amyloid precursor protein trafficking. BioVision’s QuickDetect™ 24-OHC ELISA kit is a sandwich ELISA assay for measuring the quantity of human 24-OHC in serum, plasma and cell culture and other biological fluid. The entire process can be performed within 90 minutes with only a single incubation and a wash step respectively, resulting in fewer handling steps, fewer errors and more consistent results.
CAS Number
7732-18-5
Reactivity
Human
Applications
This ELISA kit is used for quantitative measurement of 24-OHC in human serum, plasma, cell culture supernatant and other biological fluids.
Detection Method
Absorbance (450 nm)
Features & Benefits
Easy, convenient and time-saving method to measure the level of 24-OHC in human serum, plasma, culture supernatants and other biological fluids. The entire assay can be performed within 90 minutes with only a single incubation and a wash step respectively, resulting in fewer handling steps, fewer errors and more consistent results. Detection Range: 0.5 -100 ng/ml
Shipping Conditions
gel pack
Storage Conditions
4°C
Shelf Life
6 months

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