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Flunisolide (hemihydrate)

CAT: 0804-HY-B1121ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1121ASize:1 Each
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Description
Flunisolide hemihydrate is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide hemihydrate can induce eosinophil apoptosis, and is used for the research of asthma or rhinitis, and inflammation[1][2].
CAS Number
77326-96-6
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Apoptosis; Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/flunisolide-hemihydrate.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@@]3(C(CO)=O)[C@@](OC(C)(O3)C)([H])C[C@@]1([H])[C@]4([H])C[C@H](F)C5=CC(C=C[C@]5(C)[C@@]4([H])[C@@H](O)C2)=O.[1/2].O
Molecular Formula
C24H31FO6.1/2H2O
Molecular Weight
443.51
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
References & Citations
[1]Tatiana Paula Teixeira Ferreira, et al. Intranasal Flunisolide Suppresses Pathological Alterations Caused by Silica Particles in the Lungs of Mice. Front Endocrinol (Lausanne) . 2020 Jun 17;11:388. |[2]M Profita, et al. In vitro effects of flunisolide on MMP-9, TIMP-1, fibronectin, TGF-beta1 release and apoptosis in sputum cells freshly isolated from mild to moderate asthmatics. Allergy. 2004 Sep;59 (9) :927-32. |[3]S Boero, et al. Modulation by flunisolide of tumor necrosis factor-alpha-induced stimulation of airway epithelial cell activities related to eosinophil inflammation. J Asthma. 2010 May;47 (4) :381-7. |[4]B I Florea, et al. Evidence of P-glycoprotein mediated apical to basolateral transport of flunisolide in human broncho-tracheal epithelial cells (Calu-3) . Br J Pharmacol. 2001 Dec;134 (7) :1555-63.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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