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TML-6

CAT: 0804-HY-137315-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-137315-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ) . TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimer’s disease (AD) research[1].
CAS Number
1462868-88-7
UNSPSC
12352005
Target
Amyloid-β; Keap1-Nrf2; mTOR; NF-κB
Type
Reference compound
Related Pathways
Neuronal Signaling; NF-κB; PI3K/Akt/mTOR
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tml-6.html
Purity
99.01
Solubility
DMSO : 120 mg/mL (ultrasonic)
Smiles
O=C(N(CC)CC)CC(C)(C(/C=C/C1=CC=C(OC)C(OC)=C1)=O)C(/C=C/C2=CC=C(OC)C(OC)=C2)=O
Molecular Formula
C30H37NO7
Molecular Weight
523.62
References & Citations
[1]Ih-Jen Su, et al. A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer's Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model. Int J Mol Sci. 2020 Jul 30;21 (15) :5459.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MTOR; NF-κB

Chemical Information

(E)-6-(3,4-dimethoxyphenyl)-3-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]-N,N-diethyl-3-methyl-4-oxohex-5-enamide
CAS Number1462868-88-7
PubChem CID72705569
IUPAC Name(E)-6-(3,4-dimethoxyphenyl)-3-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]-N,N-diethyl-3-methyl-4-oxohex-5-enamide
Molecular FormulaC30H37NO7
Molecular Weight523.6
XLogP4.4
Topological Polar Surface Area91.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count14
Heavy Atom Count38
Formal Charge0
Complexity782
SMILES
CCN(C(=O)CC(C(=O)/C=C/C1=CC(=C(C=C1)OC)OC)(C(=O)/C=C/C2=CC(=C(C=C2)OC)OC)C)CC
InChI
InChI=1S/C30H37NO7/c1-8-31(9-2)29(34)20-30(3,27(32)16-12-21-10-14-23(35-4)25(18-21)37-6)28(33)17-13-22-11-15-24(36-5)26(19-22)38-7/h10-19H,8-9,20H2,1-7H3/b16-12+,17-13+
InChIKey
UWVCYNXVZRDWSD-UNZYHPAISA-N
Chemical Structure
2D Structure
2D structure of (E)-6-(3,4-dimethoxyphenyl)-3-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]-N,N-diethyl-3-methyl-4-oxohex-5-enamide
CAS: 1462868-88-7
CID: 72705569
Formula: C30H37NO7
MW: 523.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight523.6
XLogP34.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count14
Exact Mass523.25700252
Monoisotopic Mass523.25700252
Topological Polar Surface Area91.4 Ų
Heavy Atom Count38
Formal Charge0
Complexity782
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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