TML-6

CAT: 0804-HY-137315-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-137315-01Size:5 mg
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AVAILABILITY: InStock
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Description
TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ) . TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimer’s disease (AD) research[1].
CAS Number
[1462868-88-7]
UNSPSC
12352005
Target
Amyloid-β; Keap1-Nrf2; mTOR; NF-κB
Type
Reference compound
Related Pathways
Neuronal Signaling; NF-κB; PI3K/Akt/mTOR
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tml-6.html
Purity
99.01
Solubility
DMSO : 120 mg/mL (ultrasonic)
Smiles
O=C(N(CC)CC)CC(C)(C(/C=C/C1=CC=C(OC)C(OC)=C1)=O)C(/C=C/C2=CC=C(OC)C(OC)=C2)=O
Molecular Formula
C30H37NO7
Molecular Weight
523.62
References & Citations
[1]Ih-Jen Su, et al. A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer's Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model. Int J Mol Sci. 2020 Jul 30;21 (15) :5459.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MTOR; NF-κB

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