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PE 22-28

CAT: 0804-HY-P3581-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P3581-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression[1].
CAS Number
1801959-12-5
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pe-22-28.html
Purity
99.98
Solubility
H2O : 21.7 mg/mL (ultrasonic; warming)
Smiles
O=C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)CN
Molecular Formula
C35H55N11O9
Molecular Weight
773.88
References & Citations
[1]Alaeddine Djillani, et al. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity. Front Pharmacol. 2017 Sep 12;8:643.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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