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(±) 8 (9) -EpETE

CAT: 0804-HY-130309-01Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-130309-01Size:25 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Eicosapentaenoic acid (EPA) is converted to epoxyeicosatetraenoic acids (EpETEs) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±) 17 (18) -EpETE, relaxes vascular and airway smooth muscle by activating large conductance Ca2+-activated K+ (BKCa) channels by directly interacting with BKα channel subunits. (±) 8 (9) -EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo.
CAS Number
851378-93-3
Product Name Alternative
(±) 8,9-EEQ; (±) 8,9-epoxy Eicosatetraenoic acid
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/racemic-8-9-epete.html
Smiles
CC/C=C\C/C=C\C/C=C\CC1C(C/C=C\CCCC(O)=O)O1
Molecular Formula
C20H30O3
Molecular Weight
318.45
References & Citations
[1]Lauterbach, et al. Cytochrome P450-dependent eicosapentaenoic acid metabolites are novel BK channel activators. Hypertension 39 (2 Pt. 2), 609-613 (2002) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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