PAP-1

• Description :

  PAP-1 (5- (4-Phenoxybutoxy) psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM) . PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects[1][2].

• Product Name Alternative :

  5- (4-Phenoxybutoxy) psoralen

• UNSPSC :

  12352005

• Hazard Statement :

  H334

• Target :

  Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/PAP-1.html

• Purity :

  99.83

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C1C=CC(C(O1)=CC2=C3C=CO2)=C3OCCCCOC4=CC=CC=C4

• Molecular Formula :

  C21H18O5

• Molecular Weight :

  350.36

• Precautions :

  H334

• References & Citations :

  [1]Schmitz A, et al. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol Pharmacol. 2005 Nov;68 (5) :1254-70.|[2]Pereira LE, et al. Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5- (4-phenoxybutoxy) psoralen in rhesus macaques. Exp Biol Med (Maywood) . 2007 Nov;232 (10) :1338-54.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [870653-45-5]