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PAP-1

CAT: 0804-HY-10015-01Size: 5 mgDry Ice: NoHazardous: No
CAT#: HY-10015-01Size: 5 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PAP-1 (5- (4-Phenoxybutoxy) psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM) . PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects[1][2].
CAS Number
[870653-45-5]
Product Name Alternative
5- (4-Phenoxybutoxy) psoralen
UNSPSC
12352005
Hazard Statement
H334
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PAP-1.html
Purity
99.83
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C=CC(C(O1)=CC2=C3C=CO2)=C3OCCCCOC4=CC=CC=C4
Molecular Formula
C21H18O5
Molecular Weight
350.36
Precautions
H334
References & Citations
[1]Schmitz A, et al. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol Pharmacol. 2005 Nov;68 (5) :1254-70.|[2]Pereira LE, et al. Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5- (4-phenoxybutoxy) psoralen in rhesus macaques. Exp Biol Med (Maywood) . 2007 Nov;232 (10) :1338-54.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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