Products for Research Use Only
RegisterLogin

NAT

CAT: 0804-HY-144776-03Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-144776-03Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
NAT is an initial hit of NAMPT activator with an EC50 of 5.7 μM and a KD of 379 nM. NAMPT is the rate-limiting enzyme in the NAD salvage pathway, which makes it an attractive target for the research of many diseases associated with NAD exhaustion such as neurodegenerative diseases[1].
CAS Number
831243-31-3
UNSPSC
12352005
Target
NAMPT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nat.html
Purity
99.85
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(C)(C1=C(C=CC=C1)OCC(NC2=CC=C(C=C2)O)=O)C
Molecular Formula
C18H21NO3
Molecular Weight
299.36
References & Citations
[1]Wang L, et al. Optimization of NAMPT activators to achieve in vivo neuroprotective efficacy [published online ahead of print, 2022 Mar 16]. Eur J Med Chem. 2022;236:114260.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-(2-(tert-Butyl)phenoxy)-N-(4-hydroxyphenyl)acetamide
CAS Number831243-31-3
PubChem CID2975850
IUPAC Name2-(2-tert-butylphenoxy)-N-(4-hydroxyphenyl)acetamide
Molecular FormulaC18H21NO3
Molecular Weight299.4
XLogP4.3
Topological Polar Surface Area58.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count22
Formal Charge0
Complexity356
SMILES
CC(C)(C)C1=CC=CC=C1OCC(=O)NC2=CC=C(C=C2)O
InChI
InChI=1S/C18H21NO3/c1-18(2,3)15-6-4-5-7-16(15)22-12-17(21)19-13-8-10-14(20)11-9-13/h4-11,20H,12H2,1-3H3,(H,19,21)
InChIKey
RUNXUUCDTNJFME-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(2-(tert-Butyl)phenoxy)-N-(4-hydroxyphenyl)acetamide
CAS: 831243-31-3
CID: 2975850
Formula: C18H21NO3
MW: 299.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight299.4
XLogP34.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass299.15214353
Monoisotopic Mass299.15214353
Topological Polar Surface Area58.6 Ų
Heavy Atom Count22
Formal Charge0
Complexity356
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-180326NAT6-297775
HY-145954NAT2-IN-1
HY-161875-01NAT1-IN-1
HY-P705422-01NAT1, Human (His)
HY-P87633NAT1 Antibody (YA7317, Rabbit)
HY-P83543-01NAT1 Antibody (YA3288, Rabbit)
HY-RS09039NAT1 Human Pre-designed siRNA Set A
HY-RS09043NAT8 Human Pre-designed siRNA Set A
HY-RS09045NAT9 Human Pre-designed siRNA Set A
HY-RS17410Nat2 Mouse Pre-designed siRNA Set A

Alternative Products

CatalogName
303-150Riboclear (RNA Cleanup)
TBS10485-100Tribio InVivoMAb Anti-Mouse TIGIT & PD-L1 Bispecific Antibody
TBS10191-1mgTetrahydrocannabinol (THC) Monoclonal Antibody
TBI3024-25MGAc-Leu-Leu-Nle-CHO (ALLN), Calpain inhibitor
122-101ExgeneTM Forensic SV mini
TBS10483-100Tribio InVivoMAb Anti-Mouse PD-L1 & CD28 Bispecific Antibody
TBS10183-1mgMonoclonal Anti-Thyroid Stimulating Hormone (TSH) Antibody
TBS10340-0.5MGInVivo Mouse IgG1 Isotype Control Antibody
121-220Exfection Plasmid EF (Exdotoxin Free, Midi)
TBS10482-100Tribio InVivoMAb Anti-Mouse PD-L1 & OX40 Bispecific Antibody

Popular Products