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AGN-195183

CAT: 0804-HY-16684-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16684-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AGN-195183 (IRX-5183) is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836. AGN-195183 has no activity on RARβ/γ.
CAS Number
367273-07-2
Product Name Alternative
IRX-5183; VTP-195183; NRX-195183
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; RAR/RXR
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/agn-195183.html
Concentration
10mM
Purity
99.75
Solubility
DMSO : 11 mg/mL (ultrasonic)
Smiles
O=C(O)C1=C(F)C=C(NC(C2=C(O)C(Cl)=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1F
Molecular Formula
C22H22ClF2NO4
Molecular Weight
437.86
Precautions
H302, H315, H319, H335
References & Citations
[1]Beard RL, et al. Synthesis and biological activity of retinoic acid receptor-alpha specific amides. Bioorg Med Chem Lett. 2002 Nov 4;12 (21) :3145-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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