Thrombopoietin Receptor (c-Mpl) (TPO)

• Catalog number
  MBS617444
• Price
  Please ask
• Size
  5x0.2 mg

• Products_type
  Antibody
• Products_short_name
  [Thrombopoietin Receptor]
• Products_name_syn
  [Anti -Thrombopoietin Receptor (c-Mpl) (TPO)]
• Other_names
  [thrombopoietin receptor; Thrombopoietin receptor; thrombopoietin receptor; TPO-R; OTTHUMP00000008582; OTTHUMP00000008583; proto-oncogene c-Mpl; myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl]
• Other_gene_names
  [MPL; MPL; MPLV; TPOR; C-MPL; CD110; TPOR]
• Reactivity
  Human
• Specificity
  Recognizes glycosylated and unglycosylated human TPO receptor/c-Mpl, Mr 70kD. Species Crossreactivity: mouse
• Purity
  Purified by Protein A affinity chromatography.
• Form
  Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide, 30% glycerol.
• Concentration
  1mg/ml
• Storage_stability
  May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Tested_application
  Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  Thrombopoietin   Receptor   c-Mpl   TPO  
• Gene symbol
  TPO, THPO
• Short name
  Thrombopoietin Receptor (c-Mpl) (TPO)
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  Thrombopoietin Receptor (c-myeloproliferative leukemia virus oncogene) (TPO)
• Alternative to gene target
  myeloproliferative leukemia virus oncogene, C-MPL and CD110 and MPLV and THCYT2 and TPOR, MPL and IDBG-97403 and ENSG00000117400 and 4352, protein binding, Plasma membranes, Mpl and IDBG-181592 and ENSMUSG00000006389 and 17480, BT.26255 and IDBG-640482 and ENSBTAG00000003781 and 528492

Gene info

• Identity
  HGNC:12015
• Gene
  TPO
• Long gene name
  thyroid peroxidase
• Synonyms
  • TPX
• Locus
  2p25.3
• Discovery year
  1986-01-01
• Entrez gene record
  7173
• RefSeq identity
  • NM_000547
• Classification
  • Sushi domain containing
• VEGA ID
  OTTHUMG00000090271

Gene info

• Identity
  HGNC:11795
• Gene
  THPO
• Long gene name
  thrombopoietin
• Synonyms gene
  • MGDF
• Synonyms
  • TPO
  • MPLLG
• Synonyms name
  • prepro-thrombopoietin
  • megakaryocyte stimulating factor
  • myeloproliferative leukemia virus oncogene ligand
  • megakaryocyte growth and development factor
  • MPL ligand
  • megakaryocyte colony-stimulating factor
  • c-mpl ligand
  • thrombopoietin nirs variant 1
• Locus
  3q27.1
• Discovery year
  1994-11-04
• Entrez gene record
  7066
• Pubmed identfication
  • 8202154
• RefSeq identity
  • NM_000460
• Classification
  • Receptor ligands
• VEGA ID
  OTTHUMG00000156745
• Locus Specific Databases
  • LRG_580

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