Thrombopoietin Receptor (TPO-R, Myeloproliferative Leukemia Protein, Proto-oncogene c-Mpl, CD110, TPOR) (PE)

Catalog number

MBS646918
Price

Please ask
Size

5x100 Tests

Products_type

Antibody
Products_short_name

[Thrombopoietin Receptor]
Products_name_syn

[Anti -Thrombopoietin Receptor (TPO-R, Myeloproliferative Leukemia Protein, Proto-oncogene c-Mpl, CD110, TPOR) (PE)]
Other_names

[thrombopoietin receptor; Thrombopoietin receptor; thrombopoietin receptor; TPO-R; proto-oncogene c-Mpl; myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl]
Other_gene_names

[MPL; MPL; MPLV; TPOR; C-MPL; CD110; THCYT2; TPOR; TPO-R]
Clonality

Monoclonal
Clone

[11D72]
Reactivity

Human
Specificity

Recognizes human Thrombopoietin R. No crossreactivity with recombinant mouse Thrombopoietin R or recombinant human Erythropoietin R.
Purity

Purified by Protein A affinity chromatography from hybridoma culture supernatant
Form

Supplied as a liquid in saline, ?0.5% BSA, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).
Concentration

0.025ng/ml
Storage_stability

Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Tested_application

Flow Cytometry (FC/FACS)
Description

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Gene target

Thrombopoietin Receptor TPO-R Myeloproliferative Leukemia Protein Proto-oncogene c-Mpl CD110 TPOR
Gene symbol

MPL, TPO, THPO, RRAS, DAD1P1, HNRNPR, CLDN4, MC1R, CTNNA2, PTPRK
Short name

Thrombopoietin Receptor (TPO-R, Myeloproliferative Leukemia Protein, Proto-oncogene c-Mpl, CD110, TPOR) (PE)
Host

Mouse
Isotype

IgG2a
Label

PE
Alternative name

Thrombopoietin Receptor (TPO-R, Myeloproliferative Leukemia Protein, Proto-oncogene c-myeloproliferative leukemia virus oncogene, CD110, TPOR) (peroxidase)
Alternative to gene target

myeloproliferative leukemia virus oncogene, C-MPL and CD110 and MPLV and THCYT2 and TPOR, MPL and IDBG-97403 and ENSG00000117400 and 4352, protein binding, Plasma membranes, Mpl and IDBG-181592 and ENSMUSG00000006389 and 17480, BT.26255 and IDBG-640482 and ENSBTAG00000003781 and 528492
Virus

leukemia

Gene info

Identity

HGNC:7217
Gene

MPL
Long gene name

MPL proto-oncogene, thrombopoietin receptor
Synonyms gene name
- myeloproliferative leukemia virus oncogene
Synonyms
- CD110
- TPOR
- THPOR
GenBank acession
- M90102
Locus

1p34.2
Discovery year

1990-09-10
Entrez gene record

4352
Pubmed identfication
- 1608974
RefSeq identity
- NM_005373
Classification
- Fibronectin type III domain containing
- CD molecules
VEGA ID

OTTHUMG00000007429
Locus Specific Databases
- LRG_510

Gene info

Identity

HGNC:12015
Gene

TPO
Long gene name

thyroid peroxidase
Synonyms
- TPX
Locus

2p25.3
Discovery year

1986-01-01
Entrez gene record

7173
RefSeq identity
- NM_000547
Classification
- Sushi domain containing
VEGA ID

OTTHUMG00000090271

Gene info

Identity

HGNC:11795
Gene

THPO
Long gene name

thrombopoietin
Synonyms gene
- MGDF
Synonyms
- TPO
- MPLLG
Synonyms name
Locus

3q27.1
Discovery year

1994-11-04
Entrez gene record

7066
Pubmed identfication
- 8202154
RefSeq identity
- NM_000460
Classification
- Receptor ligands
VEGA ID

OTTHUMG00000156745
Locus Specific Databases
- LRG_580

Gene info

Identity

HGNC:10447
Gene

RRAS
Long gene name

RAS related
Synonyms gene name
- related RAS viral (r-ras) oncogene homolog
Synonyms
- R-Ras
Synonyms name
- Oncogene RRAS
Locus

19q13.33
Discovery year

2001-06-22
Entrez gene record

6237
Pubmed identfication
- 3098437
RefSeq identity
- NM_006270
Classification
- RAS type GTPase family
VEGA ID

OTTHUMG00000183247

Gene info

Identity

HGNC:18295
Gene

DAD1P1
Long gene name

defender against cell death 1 pseudogene 1
Synonyms gene
- DAD1L
Synonyms gene name
- defender against cell death 1-like
Synonyms
- DAD-R
Locus

12p12.1
Discovery year

2007-07-26
Entrez gene record

56286
Pubmed identfication
- 10812081
- 11912161
RefSeq identity
- NR_024064

Gene info

Identity

HGNC:5047
Gene

HNRNPR
Long gene name

heterogeneous nuclear ribonucleoprotein R
Synonyms gene
- HNRPR
Synonyms
- hnRNP-R
GenBank acession
- AF000364
Locus

1p36.12
Discovery year

1999-06-11
Entrez gene record

10236
Pubmed identfication
- 9421497
RefSeq identity
- NM_005826
Classification
- Heterogeneous nuclear ribonucleoproteins
- RNA binding motif containing
VEGA ID

OTTHUMG00000003224

Gene info

Identity

HGNC:2046
Gene

CLDN4
Long gene name

claudin 4
Synonyms gene
- CPETR
- CPETR1
Synonyms
- CPE-R
- WBSCR8
- hCPE-R
Synonyms name
- Clostridium perfringens enterotoxin receptor 1
- Williams-Beuren syndrome chromosomal region 8 protein
GenBank acession
- AB000712
Locus

7q11.23
Discovery year

1998-04-22
Entrez gene record

1364
Pubmed identfication
- 9334247
- 9892664
RefSeq identity
- NM_001305
Classification
- Claudins
VEGA ID

OTTHUMG00000023425

Gene info

Identity

HGNC:6929
Gene

MC1R
Long gene name

melanocortin 1 receptor
Synonyms gene name
- melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Synonyms
- MSH-R
Synonyms name
- alpha melanocyte stimulating hormone receptor
Locus

16q24.3
Discovery year

1993-07-27
Entrez gene record

4157
Pubmed identfication
- 8458079
RefSeq identity
- NM_002386
Classification
- Melanocortin receptors
VEGA ID

OTTHUMG00000171163

Gene info

Identity

HGNC:2510
Gene

CTNNA2
Long gene name

catenin alpha 2
Synonyms gene name
- catenin (cadherin-associated protein), alpha 2
Synonyms
- CAP-R
- CT114
Synonyms name
Locus

2p12
Discovery year

1993-07-13
Entrez gene record

1496
Pubmed identfication
- 8432524
RefSeq identity
- NM_004389
Classification
- Alpha catenins
VEGA ID

OTTHUMG00000152903

Gene info

Identity

HGNC:9674
Gene

PTPRK
Long gene name

protein tyrosine phosphatase receptor type K
Synonyms
- R-PTP-kappa
GenBank acession
- L77886
Locus

6q22.33
Discovery year

1998-02-09
Entrez gene record

5796
Pubmed identfication
- 9047348
- 8663237
Classification
- Protein tyrosine phosphatases receptor type
- Fibronectin type III domain containing
- Immunoglobulin like domain containing
VEGA ID

OTTHUMG00000015536

MeSH Data

Name

Leukemia, Experimental
Concept

Scope note: Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.
Tree numbers
- C04.557.337.372
- C04.619.531
- E05.598.500.496.500
Qualifiers

diagnosis, parasitology, immunology, microbiology, diagnostic imaging, physiopathology, rehabilitation, enzymology, etiology, mortality, epidemiology, blood, cerebrospinal fluid, chemically induced, congenital, diet therapy, drug therapy, therapy, psychology, urine, virology, history, classification, economics, embryology, genetics, nursing, radiotherapy, ethnology, prevention & control, pathology, metabolism, complications, surgery

Thrombopoietin Receptor (TPO-R, Myeloproliferative Leukemia Protein, Proto-oncogene c-Mpl, CD110, TPOR) (PE)

Gene info

Gene info

Gene info

Gene info

Gene info

Gene info

Gene info

Gene info

Gene info

Gene info

MeSH Data

Product images

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