Thrombopoietin Receptor (TPO-R, Myeloproliferative Leukemia Protein, Proto-oncogene c-Mpl, CD110, TPOR)

• Catalog number
  MBS629909
• Price
  Please ask
• Size
  100ug

• Alternative name1
  Anti-Thrombopoietin Receptor (TPO-R, Myeloproliferative Leukemia Protein, Proto-oncogene c-Mpl, CD110, TPOR)
• Alternative name2
  Thrombopoietin Receptor (TPO-R, Myeloproliferative Leukemia Protein, Proto-oncogene c-Mpl, CD110, TPOR)
• Alternative name3
  Thrombopoietin Receptor (TPO-R, MyeloprolifeRattus norvegicusive Leukemia Protein, Proto-oncogene c-Mpl, CD110, TPOR)
• Alternative name4
  Thrombopoietin Receptor
• Alternative name5
  Anti -Thrombopoietin Receptor (TPO-R, Myeloproliferative Leukemia Protein, Proto-oncogene c-Mpl, CD110, TPOR)
• Other names
  thrombopoietin receptor; Thrombopoietin receptor; thrombopoietin receptor; TPO-R; OTTHUMP00000008582; OTTHUMP00000008583; proto-oncogene c-Mpl; myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl
• Gene name
  N/A
• Gene name synonims
  N/A
• Other gene names
  MPL; MPL; MPLV; TPOR; C-MPL; CD110; TPOR
• Category
  Antibodies
• Clonality
  Polyclonal
• Immunoglobulin isotype
  N/A
• Clone
  Polyclonal antibody
• Host organism
  Host: Rabbit; Source: Human
• Species reactivity
  Human
• Specificity and cross reactivity
  Recognizes human MPL.
• Purification method
  Purified.
• Form Appearance
  Supplied as a liquid in PBS, pH 7.2.
• Concentration
  N/A
• Storage and shipping
  Store at 4 degrees Celsius for short term storage.. Aliquot to avoid repeated freezing and thawing. For optimal long term storage, productone should be kept at -20 degrees Celsius. Aliquots are stable for at least 12 months. For maximum recovery of product, 11c7entrifuge the original vial after thawing and prior to removing the cap.
• Tested for
  Western Blot (WB)
• Description
  productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
• Advisory
  In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Additional description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  Thrombopoietin   Receptor   TPO-R   Myeloproliferative   Leukemia   Protein   Proto-oncogene   c-Mpl   CD110   TPOR  
• Gene symbol
  MPL, TPO, THPO, RRAS, DAD1P1, HNRNPR, CLDN4, MC1R, PTPRK, CTNNA2
• Short name
  Thrombopoietin Receptor (TPO-R, Myeloproliferative Leukemia Protein, Proto-oncogene c-Mpl, CD110, TPOR)
• Alternative name
  Thrombopoietin Receptor (TPO-R, Myeloproliferative Leukemia Protein, Proto-oncogene c-myeloproliferative leukemia virus oncogene, CD110, TPOR)
• Alternative to gene target
  myeloproliferative leukemia virus oncogene, C-MPL and CD110 and MPLV and THCYT2 and TPOR, MPL and IDBG-97403 and ENSG00000117400 and 4352, protein binding, Plasma membranes, Mpl and IDBG-181592 and ENSMUSG00000006389 and 17480, BT.26255 and IDBG-640482 and ENSBTAG00000003781 and 528492
• Virus
  leukemia

Gene info

• Identity
  HGNC:7217
• Gene
  MPL
• Long gene name
  MPL proto-oncogene, thrombopoietin receptor
• Synonyms gene name
  • myeloproliferative leukemia virus oncogene
• Synonyms
  • CD110
  • TPOR
  • THPOR
• GenBank acession
  • M90102
• Locus
  1p34.2
• Discovery year
  1990-09-10
• Entrez gene record
  4352
• Pubmed identfication
  • 1608974
• RefSeq identity
  • NM_005373
• Classification
  • Fibronectin type III domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000007429
• Locus Specific Databases
  • LRG_510

Gene info

• Identity
  HGNC:12015
• Gene
  TPO
• Long gene name
  thyroid peroxidase
• Synonyms
  • TPX
• Locus
  2p25.3
• Discovery year
  1986-01-01
• Entrez gene record
  7173
• RefSeq identity
  • NM_000547
• Classification
  • Sushi domain containing
• VEGA ID
  OTTHUMG00000090271

Gene info

• Identity
  HGNC:11795
• Gene
  THPO
• Long gene name
  thrombopoietin
• Synonyms gene
  • MGDF
• Synonyms
  • TPO
  • MPLLG
• Synonyms name
  • prepro-thrombopoietin
  • megakaryocyte stimulating factor
  • myeloproliferative leukemia virus oncogene ligand
  • megakaryocyte growth and development factor
  • MPL ligand
  • megakaryocyte colony-stimulating factor
  • c-mpl ligand
  • thrombopoietin nirs variant 1
• Locus
  3q27.1
• Discovery year
  1994-11-04
• Entrez gene record
  7066
• Pubmed identfication
  • 8202154
• RefSeq identity
  • NM_000460
• Classification
  • Receptor ligands
• VEGA ID
  OTTHUMG00000156745
• Locus Specific Databases
  • LRG_580

Gene info

• Identity
  HGNC:10447
• Gene
  RRAS
• Long gene name
  RAS related
• Synonyms gene name
  • related RAS viral (r-ras) oncogene homolog
• Synonyms
  • R-Ras
• Synonyms name
  • Oncogene RRAS
• Locus
  19q13.33
• Discovery year
  2001-06-22
• Entrez gene record
  6237
• Pubmed identfication
  • 3098437
• RefSeq identity
  • NM_006270
• Classification
  • RAS type GTPase family
• VEGA ID
  OTTHUMG00000183247

Gene info

• Identity
  HGNC:18295
• Gene
  DAD1P1
• Long gene name
  defender against cell death 1 pseudogene 1
• Synonyms gene
  • DAD1L
• Synonyms gene name
  • defender against cell death 1-like
• Synonyms
  • DAD-R
• Locus
  12p12.1
• Discovery year
  2007-07-26
• Entrez gene record
  56286
• Pubmed identfication
  • 10812081
  • 11912161
• RefSeq identity
  • NR_024064

Gene info

• Identity
  HGNC:5047
• Gene
  HNRNPR
• Long gene name
  heterogeneous nuclear ribonucleoprotein R
• Synonyms gene
  • HNRPR
• Synonyms
  • hnRNP-R
• GenBank acession
  • AF000364
• Locus
  1p36.12
• Discovery year
  1999-06-11
• Entrez gene record
  10236
• Pubmed identfication
  • 9421497
• RefSeq identity
  • NM_005826
• Classification
  • Heterogeneous nuclear ribonucleoproteins
  • RNA binding motif containing
• VEGA ID
  OTTHUMG00000003224

Gene info

• Identity
  HGNC:2046
• Gene
  CLDN4
• Long gene name
  claudin 4
• Synonyms gene
  • CPETR
  • CPETR1
• Synonyms
  • CPE-R
  • WBSCR8
  • hCPE-R
• Synonyms name
  • Clostridium perfringens enterotoxin receptor 1
  • Williams-Beuren syndrome chromosomal region 8 protein
• GenBank acession
  • AB000712
• Locus
  7q11.23
• Discovery year
  1998-04-22
• Entrez gene record
  1364
• Pubmed identfication
  • 9334247
  • 9892664
• RefSeq identity
  • NM_001305
• Classification
  • Claudins
• VEGA ID
  OTTHUMG00000023425

Gene info

• Identity
  HGNC:6929
• Gene
  MC1R
• Long gene name
  melanocortin 1 receptor
• Synonyms gene name
  • melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
• Synonyms
  • MSH-R
• Synonyms name
  • alpha melanocyte stimulating hormone receptor
• Locus
  16q24.3
• Discovery year
  1993-07-27
• Entrez gene record
  4157
• Pubmed identfication
  • 8458079
• RefSeq identity
  • NM_002386
• Classification
  • Melanocortin receptors
• VEGA ID
  OTTHUMG00000171163

Gene info

• Identity
  HGNC:9674
• Gene
  PTPRK
• Long gene name
  protein tyrosine phosphatase receptor type K
• Synonyms
  • R-PTP-kappa
• GenBank acession
  • L77886
• Locus
  6q22.33
• Discovery year
  1998-02-09
• Entrez gene record
  5796
• Pubmed identfication
  • 9047348
  • 8663237
• Classification
  • Protein tyrosine phosphatases receptor type
  • Fibronectin type III domain containing
  • Immunoglobulin like domain containing
• VEGA ID
  OTTHUMG00000015536

Gene info

• Identity
  HGNC:2510
• Gene
  CTNNA2
• Long gene name
  catenin alpha 2
• Synonyms gene name
  • catenin (cadherin-associated protein), alpha 2
• Synonyms
  • CAP-R
  • CT114
• Synonyms name
  • cadherin-associated protein, related
  • cancer/testis antigen 114
  • alpha-N-catenin
• Locus
  2p12
• Discovery year
  1993-07-13
• Entrez gene record
  1496
• Pubmed identfication
  • 8432524
• RefSeq identity
  • NM_004389
• Classification
  • Alpha catenins
• VEGA ID
  OTTHUMG00000152903

MeSH Data

• Name
  Leukemia, Experimental
• Concept
  Scope note: Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.
• Tree numbers
  • C04.557.337.372
  • C04.619.531
  • E05.598.500.496.500
• Qualifiers
  diagnosis, parasitology, immunology, microbiology, diagnostic imaging, physiopathology, rehabilitation, enzymology, etiology, mortality, epidemiology, blood, cerebrospinal fluid, chemically induced, congenital, diet therapy, drug therapy, therapy, psychology, urine, virology, history, classification, economics, embryology, genetics, nursing, radiotherapy, ethnology, prevention & control, pathology, metabolism, complications, surgery

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