BACE, Asp2 (Beta-secretase 1, Aspartyl Protease 2, ASP2, Asp 2, Beta-site Amyloid Precursor Protein Cleaving Enzyme 1, Beta-site APP Cleaving Enzyme 1, Memapsin-2, Membrane-associated Aspartic Protease 2, BACE1, KIAA1149)

• Catalog number
  MBS633019
• Price
  Please ask
• Size
  5x0.1 mg

• Products_type
  Antibody
• Products_short_name
  [BACE, Asp2]
• Products_name_syn
  [Anti -BACE, Asp2 (Beta-secretase 1, Aspartyl Protease 2, ASP2, Asp 2, Beta-site Amyloid Precursor Protein Cleaving Enzyme 1, Beta-site APP Cleaving Enzyme 1, Memapsin-2, Membrane-associated Aspartic Protease 2, BACE1, KIAA1149)]
• Other_names
  [beta-secretase 1 isoform D preproprotein; Beta-secretase 1; beta-secretase 1; asp 2; memapsin-2; APP beta-secretase; aspartyl protease 2; beta-site APP cleaving enzyme 1; beta-secretase 1 precursor variant 1; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site APP-cleaving enzyme 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2]
• Other_gene_names
  [BACE1; BACE1; ASP2; BACE; HSPC104; BACE; KIAA1149; ASP2; Asp 2]
• Clonality
  Monoclonal
• Clone
  [11C83]
• Reactivity
  Human
• Specificity
  Recognizes human BACE, asp2.
• Purity
  Affinity Purified Purified by immunoaffinity chromatography.
• Form
  Supplied as a lyophilized powder from PBS, 0.1% BSA. Reconstitute with 100ul sterile PBS.
• Storage_stability
  Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
• Tested_application
  ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
• Description
  Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional. Associated membrane protein types are lipopolysaccharide selective barriers. Biological membranes include cell membranes, outer coverings of cells or organelles that allow passage of certain proteins and nuclear membranes, which cover a cell nucleus; and tissue membranes, such as mucosae and serosae. , Precursor cell, also called a blast cell or simply blast, is a type of partially differentiated, usually unipotent cell that has lost most or all of the stem cell multipotency.

• Gene target
  BACE   Asp2   Beta-secretase   Aspartyl   Protease   ASP2   Asp   Beta-site   Amyloid   Precursor   Protein   Cleaving   Beta-site   APP   Cleaving   Memapsin-2   Membrane-associated   Aspartic   Protease   BACE1   KIAA1149  
• Gene symbol
  BACE1, APP-DT, BACE1-AS, APP, PABPC4, NAE1
• Short name
  BACE, Asp2 (Beta-secretase 1, Aspartyl Protease 2, ASP2, Asp 2, Beta-site Amyloid Protein Cleaving Enzyme 1, Beta-site APP Cleaving Enzyme 1, Memapsin-2, -associated Aspartic Protease 2, BACE1, KIAA1149)
• Technique
  Enzyme, enzymes
• Host
  Mouse
• Isotype
  IgG1
• Alternative name
  BACE, Asp2 (b-secretase 1, Aspartyl Protease 2, ASP2, L-aspartic acid 2, b-site Amyloid Precursor Protein Cleaving Enzyme 1, b-site amyloid beta (A4) precursor protein Cleaving Enzyme 1, Memapsin-2, Membrane-associated Aspartic Protease 2, BACE1, KIAA1149)
• Alternative technique
  enzymes
• Alternative to gene target
  amyloid beta (A4) precursor protein, AAA and ABETA and ABPP and AD1 and APPI and CTFgamma and CVAP and PN-II and PN2, APP and IDBG-1100 and ENSG00000142192 and 351, growth factor receptor binding, nuclei, App and IDBG-172954 and ENSMUSG00000022892 and 11820, APP and IDBG-630293 and ENSBTAG00000017753 and 280722

Gene info

• Identity
  HGNC:933
• Gene
  BACE1
• Long gene name
  beta-secretase 1
• Synonyms gene
  • BACE
• Synonyms gene name
  • beta-site APP-cleaving enzyme
  • beta-site APP-cleaving enzyme 1
• GenBank acession
  • AF190725
• Locus
  11q23.3
• Discovery year
  1999-10-29
• Entrez gene record
  23621
• Pubmed identfication
  • 10531052
• Classification
  • Peptidase family A1
• VEGA ID
  OTTHUMG00000160636

Gene info

• Identity
  HGNC:55075
• Gene
  APP-DT
• Long gene name
  APP divergent transcript
• Locus
  21q21.3
• Discovery year
  2020-06-12
• Classification
  • Divergent transcripts

Gene info

• Identity
  HGNC:37125
• Gene
  BACE1-AS
• Long gene name
  BACE1 antisense RNA
• Synonyms gene
  • BACE1AS
• Synonyms gene name
  • BACE1 antisense RNA (non-protein coding)
• Synonyms
  • FJ573250
  • NCRNA00177
  • BACE1-AS1
• Synonyms name
  • non-protein coding RNA 177
• Locus
  11q23.3
• Discovery year
  2009-07-15
• Entrez gene record
  100379571
• Pubmed identfication
  • 18587408
  • 21785702
• RefSeq identity
  • NR_037803
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000188154

Gene info

• Identity
  HGNC:620
• Gene
  APP
• Long gene name
  amyloid beta precursor protein
• Synonyms gene
  • AD1
• Synonyms gene name
  • Alzheimer disease
  • amyloid beta (A4) precursor protein
• Synonyms
  • alpha-sAPP
• Synonyms name
  • peptidase nexin-II
• GenBank acession
  • M15533
• Locus
  21q21.3
• Discovery year
  1986-01-01
• Entrez gene record
  351
• Pubmed identfication
  • 1679289
• RefSeq identity
  • NM_000484
• Classification
  • Receptor ligands
• VEGA ID
  OTTHUMG00000078438
• Locus Specific Databases
  • Alzheimer Disease & Frontotemporal Dementia Mutation Database

Gene info

• Identity
  HGNC:8557
• Gene
  PABPC4
• Long gene name
  poly(A) binding protein cytoplasmic 4
• Synonyms gene name
  • poly(A)-binding protein, cytoplasmic 4 (inducible form)
  • poly(A) binding protein, cytoplasmic 4 (inducible form)
• Synonyms
  • iPABP
  • APP-1
• Synonyms name
  • activated-platelet protein 1
  • Inducible poly(A)-binding protein
• GenBank acession
  • U33818
• Locus
  1p34.3
• Discovery year
  1999-12-17
• Entrez gene record
  8761
• Pubmed identfication
  • 10543404
• RefSeq identity
  • NM_001135653
• Classification
  • RNA binding motif containing
  • Small nucleolar RNA protein coding host genes
• VEGA ID
  OTTHUMG00000009097

Gene info

• Identity
  HGNC:621
• Gene
  NAE1
• Long gene name
  NEDD8 activating enzyme E1 subunit 1
• Synonyms gene
  • APPBP1
• Synonyms gene name
  • amyloid beta precursor protein binding protein 1, 59kDa
• Synonyms
  • ula-1
  • APP-BP1
• GenBank acession
  • U50939
• Locus
  16q22.1
• Discovery year
  1999-01-13
• Entrez gene record
  8883
• Pubmed identfication
  • 8626687
  • 12740388
• RefSeq identity
  • NM_003905
• Classification
  • Ubiquitin like modifier activating enzymes
• VEGA ID
  OTTHUMG00000137513

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