Mouse Monoclonal [clone EM-20] (IgG2a) to Human PRNP / PrP / Prion Antibody
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Catalog number
GEN246500
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Price
Please ask
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Size
50ug
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Also known as
PRNP / PrP / Prion
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Other names
major prion protein preproprotein; Major prion protein; alternative prion protein; major prion protein; CD230 antigen; prion-related protein; prion protein; ASCR; PrP27-30; PrP33-35C; CD_antigen: CD230
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Category
Antibodies
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Subcategory
Mnoclonal antibodies
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Gene name
PRNP
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Gene name synonims
N/A
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Other gene names
PRNP; PRNP; CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C; ALTPRP; PRIP; PRP; PrP
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Clonality
Monoclonal
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Immunoglobulin isotype
IgG2a
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Clone
EM-20
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Host organism
Mouse (Mus musculus)
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Species reactivity
Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
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Specificity and cross reactivity
The mouse monoclonal antibody EM-20 recognizes human prion protein (PrP). Diglycosylated form of PrP has ~40 kD, monoglycosylated form ~30 kD, and nonglycosylated form ~19-21 kD. This antibody is suitable for discrimination between normal cellular prion protein (PrPc) and its conformationally changed form (PrPSc) prion protein.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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Purification method
Protein A Purified
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Form Appearance
PBS, 15 mM sodium azide, pH 7.4
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Concentration
N/A
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Storage and shipping
Store at +4 degrees Celsius for short term storage. For long term storage aliquot and keep the antibody at -20 degrees Celsius. Freeze-thaw cycles should be avoided in order to retain the activity of the antibody.
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Tested applications
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
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Properties
If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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French translation
anticorps
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Gene target
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Gene symbol
PIRC104, PIRC103, SNORD115-20, SNORD114-20, SNORD116-20, IGKV3-20, IGLVI-20
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Short name
Mouse Monoclonal [clone EM-20] (IgG2a) PRNP / PrP / Prion Antibody
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Technique
Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
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Host
mouse monoclonal, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
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Isotype
IgG2a
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Species
Human, Humans, Mouses
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Alternative name
Anti-Mouse Monoclonal [clone EM-20] (IgG2a) to Human PRNP / PrP / Prion
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Alternative technique
antibodies, murine
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Alternative to gene target
prion protein, AltPrP and ASCR and CD230 and CJD and GSS and KURU and p27-30 and PRIP and PrP and PrP27-30 and PrP33-35C and PrPc, PRNP and IDBG-49833 and ENSG00000171867 and 5621, chaperone binding, nuclei, Prnp and IDBG-260830 and ENSMUSG00000079037 and 19122, PRNP and IDBG-639760 and ENSBTAG00000027937 and 281427
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Clone name
EM-20
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Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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