PrP Antibody Prion protein

• Catalog number
  R30892
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  PrP Prion protein
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the PrP antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This PrP antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P04156
• Purity
  Antigen affinity
• Description
  Prion protein, also known as CD230 and PrP, is a protein that in humans is encoded by the PRNP gene. Expression is predominantly in the nervous system but occurs to some degree in many other tissues throughout the body. Puckett et al.(1991)identified a RFLP with a high degree of heterozygosity in the 5-prime region of the PRNP gene, which might serve as a useful marker for the pter-p12 region of chromosome 20. PrP is associated with a variety of cognitive deficiencies and neurodegenerative diseases such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and kuru. The protein is highly conserved through mammals, lending credence to application of conclusions from test animals such as mice. Comparison between primates is especially similar, ranging from 92.9-99.6% similarity in amino acid sequences.
• Immunogen
  An amino acid sequence from the middle region of human Prion protein (DYEDRYYRENMHRYPNQ) was used as the immunogen for this PrP antibody.
• Storage
  After reconstitution, the PrP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PrP   Prion   protein  
• Gene symbol
  PRNP
• Short name
  Anti-PrP Prion protein
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to PrP Prion protein
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9449
• Gene
  PRNP
• Long gene name
  prion protein
• Synonyms gene
  • PRIP
  • GSS
  • CJD
• Synonyms gene name
  • prion protein (p27-30)
• Synonyms
  • CD230
  • PRP
  • AltPrP
• Synonyms name
  • Creutzfeldt-Jakob disease
  • Gerstmann-Strausler-Scheinker syndrome
  • fatal familial insomnia
  • p27-30
• GenBank acession
  • M13899
• Locus
  20p13
• Discovery year
  1986-01-01
• Entrez gene record
  5621
• RefSeq identity
  • NM_000311
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000031786
• Locus Specific Databases
  • Prion Protein/CJD database

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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