Recombinant Human GITR Ligand/TNFSF18 Protein(C-6His) 50µg
-
Catalog number
PKSH032485-50µg
-
Price
Please ask
-
Size
50µg
-
-
Synonym
Tumor necrosis factor ligand superfamily member 18;TNFSF18;Activation-inducible TNF-related ligand;Glucocorticoid-induced TNF-related ligand;AITRL; GITRL; TL6
-
Activity
NA
-
Sequence
Glu74-Ser199
-
Fusion tag
C-6His
-
Accession
Q9UNG2
-
Expressed Host
Human cells
-
Shipping
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
-
Purity
＞90% as determined by reducing SDS-PAGE.
-
Endotoxin
＜1.0 EU per µg as determined by LAL test.
-
Stability and Storage
Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
-
Mol Mass
15.3 kDa
-
AP Mol Mass
16 &18 kDa
-
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
-
Reconstitution
Please refer to it for detailed information.
-
Background
TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.
-
-
-
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Description
FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
-
Source
Recombinants or rec. proteins
-
Group
recombinants
-
Gene target
-
Gene symbol
TNFRSF18, TNFSF18
-
Short name
Recombinant GITR Ligand/TNFSF18 Protein(C-6His) 50µg
-
Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
-
Species
Human, Humans
-
Alternative name
Rec. H. sapiens GITR Ligand/tumor necrosis factor (ligand) superfamily, member 18 Protein(C-6His) 50µg
-
Alternative technique
rec
-
Alternative to gene target
tumor necrosis factor (ligand) superfamily, member 18, AITRL and GITRL and hGITRL and TL6, TNFSF18 and IDBG-104861 and ENSG00000120337 and 8995, tumor necrosis factor receptor superfamily binding, Extracellular, Tnfsf18 and IDBG-201543 and ENSMUSG00000066755 and 240873, LOC768081 and IDBG-632315 and ENSBTAG00000047412 and 768081
-
Gene info
Gene info
MeSH Data
-
Name
-
Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
