Recombinant Human NKG2D Ligand 1/NKG2DL/ULBP1 Protein(C-6His) 50µg

• Catalog number
  PKSH032814-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  NKG2D ligand 1; N2DL-1; NKG2DL1; ALCAN-beta; Retinoic acid early transcript 1I; UL16-binding protein 1; ULBP1
• Activity
  NA
• Sequence
  Gly26-Pro215
• Fusion tag
  C-6His
• Accession
  Q9BZM6
• Expressed Host
  Human cells
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Endotoxin
  ＜1.0 EU per µg as determined by LAL test.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  23.3 kDa
• AP Mol Mass
  25-30 kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• Reconstitution
  Please refer to it for detailed information.
• Background
  ULBP1, also known as RAET1I and NKG2DL1, is a member of the ULBP/RAET1 gene family. ULBP1 plays an important role in immune responses, especially in cancer and infectious diseases, and is well-known to bind to NKG2D together with at least ULBP 2 and 3. These proteins are distantly related to major histocompatibility class I (MHC I) molecules, possessing the alpha 1 and alpha 2 Ig-like domains, but lacking the alpha 3 domain. Unlike MHC Class I, they have no capacity to bind peptide or interact with beta2-microglobulin. It can activate multiple signaling pathways in primary NK cells, gamma delta T cells, and CD8+ alpha beta T cells, resulting in the production of cytokines and chemokines.ULBP1 is expressed in wide range of tissues including heart, brain, lung, liver, bone marrow and some tumor cells, T-cells, B-cells, As an unconventional member of the MHC class I family, ULBP1 is able to interact with soluble CMV glycoprotein UL16 in CMV infected cells. The interaction with UL16 blocked the interaction with the NKG2D receptor, and thus might escape the immune surveillance. Furthermore, UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. The ULBP1 regulation may have implications for development of new therapeutic strategies against cancer cells.
• Product URL
• PDF URL
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Description
  FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  NKG2D   Ligand   1/NKG2DL/ULBP1   Protein   C-6His   50µg  
• Gene symbol
  ULBP1, KLRK1
• Short name
  Recombinant NKG2D Ligand 1/NKG2DL/ULBP1 Protein(C-6His) 50µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens NKG2D Ligand 1/NKG2DL/UL16 binding protein 1 Protein(C-6His) 50µg
• Alternative technique
  rec
• Alternative to gene target
  UL16 binding protein 1, ULBP1 and IDBG-97845 and ENSG00000111981 and 80329, natural killer cell lectin-like receptor binding, Plasma membranes

Gene info

• Identity
  HGNC:14893
• Gene
  ULBP1
• Long gene name
  UL16 binding protein 1
• Synonyms
  • RAET1I
• GenBank acession
  • AF304377
• Locus
  6q25.1
• Discovery year
  2001-04-27
• Entrez gene record
  80329
• Pubmed identfication
  • 11239445
  • 11827464
• VEGA ID
  OTTHUMG00000015810

Gene info

• Identity
  HGNC:18788
• Gene
  KLRK1
• Long gene name
  killer cell lectin like receptor K1
• Synonyms gene
  • D12S2489E
• Synonyms gene name
  • DNA segment on chromosome 12 (unique) 2489 expressed sequence
  • killer cell lectin-like receptor subfamily K, member 1
• Synonyms
  • NKG2D
  • KLR
  • NKG2-D
  • CD314
• GenBank acession
  • AJ001687
• Locus
  12p13.2
• Discovery year
  2003-12-12
• Entrez gene record
  22914
• Pubmed identfication
  • 9683661
  • 2007850
• RefSeq identity
  • NM_007360
• Classification
  • Killer cell lectin like receptors
  • C-type lectin domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000168574

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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