CD25 IL-2R alpha chain monoclonal antibody
-
Catalog number1P-614-C100
-
PricePlease ask
-
Size100ug
-
-
Long nameRat Monoclonal Antibody against Mouse CD25 IL-2R alpha chain, Clone: PC61.5
-
AntigenCD25 (mouse)
-
Species reactivityMouse (Mus musculus)
-
Negative species reactivityat the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
-
ClonalityMonoclonal Antibody (Mab)
-
ClonePC61.5
-
ApplicationsFC, IP, IHC(F), FUNC
-
ImmunogenB6.1 CTL cell line
-
Format conjugationPE
-
SpecificityThe rat monoclonal antibody PC61.5 (PC61.5.3) recognizes CD25 (Interleukin-2 receptor alpha chain), a 55 kDa type I transmembrane glycoprotein expressed on activated B and T lymphocytes, activated monocytes/macrophages and on CD4+ T lymphocytes (T regulatory cells); it is lost on resting B and T lymphocytes.
-
Research areaCD and Related Antigens & MHC (Rodent)
-
Concentration0.5 mg/ml
-
Storage bufferPhosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
-
Shipping and storageRat Monoclonal Antibody against Mouse CD25 IL-2R alpha chain, Clone: PC61.5 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
-
BackgroundCD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit CD25 constitues the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. CD25 expression rapidly increases upon T cell activation. The 55 kDa CD25 molecule is enzymatically cleaved and shed from the cell surface as a soluble 45 kDa s-Tac, whose concentration in serum can be used as a marker of T cell activation. Expression of CD25 indicates the neoplastic phenotype of mast cells. CD25+ CD4+ FoxP3+ regulatory cells (Treg cells) play a crucial role in the control of organ-specific autoimmune diseases.
-
Purity> 95% (by SDS-PAGE)
-
Purification methodPurified by affinity chromatography
-
ReferencesContact us for the most recent list of references
-
DescriptionThe Anti-CD25 IL-2R alpha chain Mab is a α- or alpha protein sometimes glycoprotein present in blood.
-
PropertiesIf you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
AboutMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
-
French translationanticorps
-
Gene target
-
Gene symbolIL2RA, VCX2, ISG20, IL36G, IL25, IL22, IL18, IL37, IL6R, IL17C
-
Short nameAnti-CD25 IL-2R alpha chain Mab
-
TechniqueAntibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
-
HostRat (Rattus norvegicus)
-
IsotypeIgG1
-
Alternative nameRat Monoclonal to CD25 (mouse) / IL-2R alpha chain
-
Alternative techniqueantibodies
-
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 2 receptor subunit alpha
-
Synonyms gene
-
Synonyms gene name
- insulin-dependent diabetes mellitus 10
- interleukin 2 receptor, alpha
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1990-01-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- CD molecules
- Sushi domain containing
- Interleukin receptors
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene namevariable charge X-linked 2
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2004-04-16
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Variable charge X/Y family
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterferon stimulated exonuclease gene 20
-
Synonyms gene name
- interferon stimulated exonuclease gene 20kDa
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1998-01-30
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Exonucleases
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 36 gamma
-
Synonyms gene
-
Synonyms gene name
- interleukin 1 family, member 9
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2002-08-02
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 25
-
Synonyms gene
-
Synonyms gene name
- interleukin 17E
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2001-01-26
-
Pubmed identfication
-
Classification
- Interleukins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 22
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2001-03-12
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 18
-
Synonyms gene name
- interleukin 18 (interferon-gamma-inducing factor)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1997-07-25
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 37
-
Synonyms gene
-
Synonyms gene name
- interleukin 1 family, member 7 (zeta)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2002-08-02
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 6 receptor
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2001-06-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- CD molecules
- Interleukin receptors
- Immunoglobulin like domain containing
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 17C
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2000-01-20
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data