Recombinant Human IL-8 / CXCL8 Protein (aa 28-99)
-
Catalog numberPKSH030277-20µg
-
PricePlease ask
-
Size20µg
-
-
SynonymGCP-1;GCP1;IL-8;IL8;Interleukin-8;LECT;LUCT;LYNAP;MDNCF;MONAP;NAF;NAP-1;NAP1
-
ActivityNA
-
SequenceSer28-Ser99
-
Fusion tagNA
-
AccessionNP_000575.1
-
Expressed HostE. coli
-
ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
-
Purity>95 % as determined by SDS-PAGE.
-
EndotoxinPlease contact us for more information.
-
Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Mol Mass8.5 kDa
-
AP Mol Mass8.5 kDa
-
FormulationLyophilized from sterile PBS, pH 7.4
-
BackgroundInterleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). In human gliomas, IL-8 is expressed and secreted at high levels both in vitro and in vivo, and recent experiments suggest it is critical to glial tumor neovascularity and progression. Levels of IL-8 correlate with histologic grade in glial neoplasms, and the most malignant form, glioblastoma, shows the highest expression in pseudopalisading cells around necrosis, suggesting that hypoxia/anoxia may stimulate expression. Interleukin (IL)-8/CXCL8 is a potent neutrophil chemotactic factor. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental changes such as hypoxia, reperfusion, and hyperoxia. Numerous observations have established IL-8/CXCL8 as a key mediator in neutrophil-mediated acute inflammation due to its potent actions on neutrophils. However, several lines of evidence indicate that IL-8/CXCL8 has a wide range of actions on various types of cells, including lymphocytes, monocytes, endothelial cells, and fibroblasts, besides neutrophils. The discovery of these biological functions suggests that IL-8/CXCL8 has crucial roles in various pathological conditions such as chronic inflammation and cancer. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression.
-
PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
SourceRecombinants or rec. proteins
-
Grouprecombinants
-
Gene target
-
Gene symbolCXCL8, SNORD114-8, IL36G, IL25, RNU6-8, IL22, SNORD113-8, IL18, IL37, SNORD116-8
-
Short nameRecombinant IL-8 / CXCL8 Protein (aa 28-99)
-
TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
-
SpeciesHuman, Humans
-
Alternative nameRec. H. sapiens Interleukin-8 / CXCL8 Protein (aa 28-99)
-
Alternative techniquerec
-
Gene info
-
Identity
-
Gene
-
Long gene nameC-X-C motif chemokine ligand 8
-
Synonyms gene
-
Synonyms gene name
- interleukin 8
- chemokine (C-X-C motif) ligand 8
-
Synonyms
-
Synonyms name
- neutrophil-activating peptide 1
- granulocyte chemotactic protein 1
- monocyte-derived neutrophil chemotactic factor
- lung giant cell carcinoma-derived chemotactic protein
- tumor necrosis factor-induced gene 1
- monocyte-derived neutrophil-activating peptide
- lymphocyte derived neutrophil activating peptide
- beta endothelial cell-derived neutrophil activating peptide
- alveolar macrophage chemotactic factor I
-
GenBank acession
-
Locus
-
Discovery year1989-06-30
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Chemokine ligands
- Interleukins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namesmall nucleolar RNA, C/D box 114-8
-
Synonyms
-
Locus
-
Discovery year2006-09-26
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Small nucleolar RNAs, C/D box
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 36 gamma
-
Synonyms gene
-
Synonyms gene name
- interleukin 1 family, member 9
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2002-08-02
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 25
-
Synonyms gene
-
Synonyms gene name
- interleukin 17E
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2001-01-26
-
Pubmed identfication
-
Classification
- Interleukins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameRNA, U6 small nuclear 8
-
Synonyms
-
Locus
-
Discovery year2008-06-10
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Small nuclear RNAs
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 22
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2001-03-12
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene namesmall nucleolar RNA, C/D box 113-8
-
Synonyms
-
Locus
-
Discovery year2006-09-20
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Small nucleolar RNAs, C/D box
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 18
-
Synonyms gene name
- interleukin 18 (interferon-gamma-inducing factor)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1997-07-25
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 37
-
Synonyms gene
-
Synonyms gene name
- interleukin 1 family, member 7 (zeta)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2002-08-02
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namesmall nucleolar RNA, C/D box 116-8
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2007-02-15
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Small nucleolar RNAs, C/D box
MeSH Data
-
Name
-
ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data