- Catalog numberPKSH030278-50µg
- Product nameRecombinant Human IL-8 / CXCL8 Protein (aa 28-99, Fc tag)
- Size50µg
- PriceAsk For Price
- SynonymGCP-1;GCP1;IL-8;IL8;Interleukin-8;LECT;LUCT;LYNAP;MDNCF;MONAP;NAF;NAP-1;NAP1
- ActivityNA
- SequenceSer 28-Ser 99
- Fusion tagN-Fc
- AccessionNP_000575.1
- Expressed HostHEK293 Cells
- ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
- Purity>90 % as determined by SDS-PAGE
- Endotoxin<1.0 EU per µg as determined by the LAL method
- Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
- Mol Mass35 kDa
- AP Mol Mass40 kDa
- FormulationLyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5
- BackgroundInterleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). In human gliomas, IL-8 is expressed and secreted at high levels both in vitro and in vivo, and recent experiments suggest it is critical to glial tumor neovascularity and progression. Levels of IL-8 correlate with histologic grade in glial neoplasms, and the most malignant form, glioblastoma, shows the highest expression in pseudopalisading cells around necrosis, suggesting that hypoxia/anoxia may stimulate expression. Interleukin (IL)-8/CXCL8 is a potent neutrophil chemotactic factor. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental changes such as hypoxia, reperfusion, and hyperoxia. Numerous observations have established IL-8/CXCL8 as a key mediator in neutrophil-mediated acute inflammation due to its potent actions on neutrophils. However, several lines of evidence indicate that IL-8/CXCL8 has a wide range of actions on various types of cells, including lymphocytes, monocytes, endothelial cells, and fibroblasts, besides neutrophils. The discovery of these biological functions suggests that IL-8/CXCL8 has crucial roles in various pathological conditions such as chronic inflammation and cancer. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression.
- Technical data
- Gene targetIL-8 / CXCL8 Protein aa 28 Fc tag
- Identity:HGNC:6025
- Gene:CXCL8
- Long gene name:C-X-C motif chemokine ligand 8
- Synonyms gene name:interleukin 8, chemokine (C-X-C motif) ligand 8
- Synonyms:SCYB8, LUCTLECTMDNCFTSG-1IL-8NAP-13-10CMONAPAMCF-ILYNAPNAFb-ENAPGCP-1K60GCP1NAP1
- Discovery year:1989-06-30
- Entrez gene record:3576
- Pubmed identification:1427896, 11178128
- RefSeq identity:NM_000584
- Classification:Chemokine ligands, Interleukins
- VEGA ID:OTTHUMG00000151316
- Identity:HGNC:32996
- Gene:SNORD114-8
- Long gene name:small nucleolar RNA, C/D box 114-8
- Synonyms:14q(II-8)
- Discovery year:2006-09-26
- Entrez gene record:767584
- Pubmed identification:12045206
- RefSeq identity:NR_003200.1
- Classification:Small nucleolar RNAs, C/D box
- Identity:HGNC:15741
- Gene:IL36G
- Long gene name:interleukin 36 gamma
- Synonyms gene name:interleukin 1 family, member 9
- Synonyms:IL-1H1IL-1RP2IL-1F9IL1H1IL1E
- Discovery year:2002-08-02
- Entrez gene record:56300
- Pubmed identification:10860666, 10744718, 11991722, 11991723
- RefSeq identity:NM_019618
- Classification:Interleukins
- VEGA ID:OTTHUMG00000131336
- Identity:HGNC:13765
- Gene:IL25
- Long gene name:interleukin 25
- Synonyms gene name:interleukin 17E
- Synonyms:IL-25IL-17E
- Discovery year:2001-01-26
- Pubmed identification:11058597, 11754819
- Classification:Interleukins
- VEGA ID:OTTHUMG00000028749
- Identity:HGNC:14900
- Gene:IL22
- Long gene name:interleukin 22
- Synonyms:ILTIFIL-21zcyto18IL-TIFIL-D110TIFaTIFIL-23IL-22MGC79382MGC79384
- Discovery year:2001-03-12
- Entrez gene record:50616
- Pubmed identification:10954742, 10875937
- RefSeq identity:NM_020525
- Classification:Interleukins
- VEGA ID:OTTHUMG00000169119
- Identity:HGNC:32987
- Gene:SNORD113-8
- Long gene name:small nucleolar RNA, C/D box 113-8
- Synonyms:14q(I-8)
- Discovery year:2006-09-20
- Entrez gene record:767568
- Pubmed identification:12045206
- RefSeq identity:NR_003236.1
- Classification:Small nucleolar RNAs, C/D box
- Identity:HGNC:5986
- Gene:IL18
- Long gene name:interleukin 18
- Synonyms gene name:interleukin 18 (interferon-gamma-inducing factor)
- Synonyms:IGIFIL1F4IL-1gIL-18
- Discovery year:1997-07-25
- Entrez gene record:3606
- Pubmed identification:7477296, 9693051
- RefSeq identity:NM_001562
- Classification:Interleukins
- VEGA ID:OTTHUMG00000167006
- Identity:HGNC:15563
- Gene:IL37
- Long gene name:interleukin 37
- Synonyms gene name:interleukin 1 family, member 7 (zeta)
- Synonyms:FIL1FIL1ZFIL1(ZETA)IL-1H4IL-1RP1IL-1F7
- Discovery year:2002-08-02
- Entrez gene record:27178
- Pubmed identification:10625660, 10512743, 12496389
- RefSeq identity:NM_014439
- Classification:Interleukins
- VEGA ID:OTTHUMG00000131345
- Identity:HGNC:33074
- Gene:SNORD116-8
- Long gene name:small nucleolar RNA, C/D box 116-8
- Synonyms:HBII-85-8
- Discovery year:2007-02-15
- Entrez gene record:100033420
- Pubmed identification:11106375, 11726556
- RefSeq identity:NR_003323
- Classification:Small nucleolar RNAs, C/D box
- Gene symbolCXCL8, SNORD114-8, IL36G, IL25, RNU6-8, IL22, SNORD113-8, IL18, IL37, SNORD116-8
- Short nameRecombinant IL-8 / CXCL8 Protein (aa 28-99, Fc tag)
- LabelFc Tag
- label filter
- Fc Tag
- technique filter
- Recombinant
- FC
- TechniqueRecombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
- Alternative techniquerec
Gene info
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Locus Specific Databases:LRG_1248