Rabbit Anti Human CBLC Antibody-Non-conjugated
-
Catalog numberCSB-PA892346ESR2HU_50ul
-
PricePlease ask
-
Size50ul
-
-
Long nameRabbit Antibody against Human CBLC, Non-conjugated
-
Synonym nameCBLC Human Antibody
-
Species reactivityHuman
-
Tested applications recommended dilutionsELISA,WB,IHC;Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
-
ConjugationNon-conjugated
-
Antibody isotypeIgG
-
UniProt IDQ9ULV8
-
FormatLiquid, diluted in buffer
-
Buffer compositionPBS with 0.02% sodium azide, 50% glycerol, pH7.3.
-
Purity>95%
-
Purification methodAntigen Affinity Purified Antibodies
-
Antibody categoryPolyclonal Antibodies
-
Immunogen typeRecombinant human E3 ubiquitin-protein ligase CBL-C protein (245-474AA)
-
Immunogen speciesHuman
-
AliasRING finger protein 57,SH3-binding protein CBL-3,SH3-binding protein CBL-C,Signal transduction protein CBL-C,CBLC,CBL3,RNF57
-
BackgroundActs as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
-
ClonalityPolyclonal antibody
-
Shipping and storageCBLC Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
-
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
-
PropertiesIf you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
AboutRabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
-
Latin nameOryctolagus cuniculus
-
French translationanticorps
-
Gene target
-
Gene symbolMMACHC, CBLC
-
Short nameAnti-CBLC
-
Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
-
HostRabbit, Rabbits
-
SpeciesHuman, Humans
-
Alternative nameCBLC Antibody
-
Alternative techniqueantibodies, rabbit-anti
-
Gene info
-
Identity
-
Gene
-
Long gene namemetabolism of cobalamin associated C
-
Synonyms gene name
- methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
-
Synonyms
-
Locus
-
Discovery year2006-01-12
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene nameCbl proto-oncogene C
-
Synonyms gene name
- Cas-Br-M (murine) ectropic retroviral transforming sequence c
- Cas-Br-M (murine) ecotropic retroviral transforming sequence c
- Cbl proto-oncogene C, E3 ubiquitin protein ligase
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2001-06-25
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Ring finger proteins
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data