Rabbit Anti Human CBL Antibody-Biotin

• Catalog number
  CSB-PA004578LD01HU_50ug
• Price
  Please ask
• Size
  50ug

• Long name
  Rabbit Antibody against Human CBL, Biotin
• Synonym name
  CBL Human Antibody
• Species reactivity
  Human
• Tested applications recommended dilutions
  ELISA
• Conjugation
  Biotin
• Antibody isotype
  IgG
• UniProt ID
  P22681
• Format
  Liquid, diluted in buffer
• Buffer composition
  Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Purity
  >95%
• Purification method
  Protein G purified
• Antibody category
  Polyclonal Antibodies
• Immunogen type
  Recombinant Human E3 ubiquitin-protein ligase CBL protein (548-847AA)
• Immunogen species
  Human
• Alias
  E3 ubiquitin-protein ligase CBL,Casitas B-lineage lymphoma proto-oncogene,Proto-oncogene c-Cbl,RING finger protein 55,Signal transduction protein CBL,CBL,CBL2,RNF55
• Background
  Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
• Clonality
  Polyclonal antibody
• Shipping and storage
  CBL Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
• Short name of the antigen
  E3 ubiquitin-protein ligase CBL
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
• Properties
  If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional conjugation
  Biotinylated
• About
  Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus
• French translation
  anticorps

• Gene target
  CBL  
• Gene symbol
  CBLC, CBL, CBLB, VTRNA2-1
• Short name
  Anti-CBL
• Technique
  anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
• Host
  Rabbit, Rabbits
• Label
  Biotin
• Species
  Human, Humans
• Alternative name
  CBL Antibody,Biotin conjugated
• Alternative technique
  antibodies, rabbit-anti
• Alternative to gene target
  Cbl proto-oncogene, E3 ubiquitin protein ligase, C-CBL and CBL2 and FRA11B and NSLL and RNF55, CBL and IDBG-74417 and ENSG00000110395 and 867, ephrin receptor binding, nuclei, Cbl and IDBG-155970 and ENSMUSG00000034342 and 12402, CBL and IDBG-631730 and ENSBTAG00000006817 and 527418

Gene info

• Identity
  HGNC:15961
• Gene
  CBLC
• Long gene name
  Cbl proto-oncogene C
• Synonyms gene name
  • Cas-Br-M (murine) ectropic retroviral transforming sequence c
  • Cas-Br-M (murine) ecotropic retroviral transforming sequence c
  • Cbl proto-oncogene C, E3 ubiquitin protein ligase
• Synonyms
  • CBL-3
  • CBL-SL
  • RNF57
• GenBank acession
  • AB028645
• Locus
  19q13.32
• Discovery year
  2001-06-25
• Entrez gene record
  23624
• Pubmed identfication
  • 10362357
  • 10571044
• RefSeq identity
  • NM_012116
• Classification
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000150715
• Locus Specific Databases
  • LRG_1161

Gene info

• Identity
  HGNC:1541
• Gene
  CBL
• Long gene name
  Cbl proto-oncogene
• Synonyms gene
  • CBL2
• Synonyms gene name
  • Cas-Br-M (murine) ecotropic retroviral transforming sequence
  • Cbl proto-oncogene, E3 ubiquitin protein ligase
• Synonyms
  • RNF55
  • c-Cbl
• Synonyms name
  • oncogene CBL2
• GenBank acession
  • X57110
• Locus
  11q23.3
• Discovery year
  1989-06-30
• Entrez gene record
  867
• Pubmed identfication
  • 2013228
• RefSeq identity
  • NM_005188
• Classification
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000166170
• Locus Specific Databases
  • LRG_608

Gene info

• Identity
  HGNC:1542
• Gene
  CBLB
• Long gene name
  Cbl proto-oncogene B
• Synonyms gene name
  • Cas-Br-M (murine) ectropic retroviral transforming sequence b
  • Cas-Br-M (murine) ecotropic retroviral transforming sequence b
  • Cbl proto-oncogene B, E3 ubiquitin protein ligase
• Synonyms
  • RNF56
  • Cbl-b
• GenBank acession
  • U26710
• Locus
  3q13.11
• Discovery year
  1995-12-18
• Entrez gene record
  868
• Pubmed identfication
  • 7784085
• RefSeq identity
  • NM_170662
• Classification
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000150654
• Locus Specific Databases
  • LRG_1179

Gene info

• Identity
  HGNC:37054
• Gene
  VTRNA2-1
• Long gene name
  vault RNA 2-1
• Synonyms gene
  • MIR886
  • MIRN886
  • VTRNA2
• Synonyms gene name
  • microRNA 886
  • vault RNA 2
• Synonyms
  • vtRNA2
  • hvg-5
  • CBL-3
  • hsa-mir-886
  • nc886
  • pre-miR-886
• Locus
  5q31.1
• Discovery year
  2009-03-23
• Entrez gene record
  100126299
• Pubmed identfication
  • 19298825
  • 19491402
  • 22926522
  • 22058117
• RefSeq identity
  • NR_030583
• Classification
  • Vault RNAs
• VEGA ID
  OTTHUMG00000183992
• Locus Specific Databases
  • LRG_1104

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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