Rabbit Anti Human CBL Antibody-HRP
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Catalog numberCSB-PA004578LB01HU_100ug
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PricePlease ask
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Size100ug
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Long nameRabbit Antibody against Human CBL, HRP
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Synonym nameCBL Human Antibody
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Species reactivityHuman
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Tested applications recommended dilutionsELISA
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ConjugationHRP
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Antibody isotypeIgG
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UniProt IDP22681
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FormatLiquid, diluted in buffer
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Buffer compositionPreservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
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Purity>95%
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Purification methodProtein G purified
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Antibody categoryPolyclonal Antibodies
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Immunogen typeRecombinant Human E3 ubiquitin-protein ligase CBL protein (548-847AA)
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Immunogen speciesHuman
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AliasE3 ubiquitin-protein ligase CBL,Casitas B-lineage lymphoma proto-oncogene,Proto-oncogene c-Cbl,RING finger protein 55,Signal transduction protein CBL,CBL,CBL2,RNF55
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BackgroundAdapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
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ClonalityPolyclonal antibody
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Shipping and storageCBL Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
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Short name of the antigenE3 ubiquitin-protein ligase CBL
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
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PropertiesIf you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional conjugationHRP Conjugated
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AboutRabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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French translationanticorps
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Gene target
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Gene symbolCBLC, CBL, CBLB, VTRNA2-1
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Short nameAnti-CBL
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Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
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HostRabbit, Rabbits
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LabelHRP
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SpeciesHuman, Humans
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Alternative nameCBL Antibody,HRP conjugated
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Alternative techniqueantibodies, rabbit-anti
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Alternative to gene targetCbl proto-oncogene, E3 ubiquitin protein ligase, C-CBL and CBL2 and FRA11B and NSLL and RNF55, CBL and IDBG-74417 and ENSG00000110395 and 867, ephrin receptor binding, nuclei, Cbl and IDBG-155970 and ENSMUSG00000034342 and 12402, CBL and IDBG-631730 and ENSBTAG00000006817 and 527418
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Gene info
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Identity
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Gene
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Long gene nameCbl proto-oncogene C
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Synonyms gene name
- Cas-Br-M (murine) ectropic retroviral transforming sequence c
- Cas-Br-M (murine) ecotropic retroviral transforming sequence c
- Cbl proto-oncogene C, E3 ubiquitin protein ligase
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Ring finger proteins
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameCbl proto-oncogene
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Synonyms gene
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Synonyms gene name
- Cas-Br-M (murine) ecotropic retroviral transforming sequence
- Cbl proto-oncogene, E3 ubiquitin protein ligase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1989-06-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Ring finger proteins
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameCbl proto-oncogene B
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Synonyms gene name
- Cas-Br-M (murine) ectropic retroviral transforming sequence b
- Cas-Br-M (murine) ecotropic retroviral transforming sequence b
- Cbl proto-oncogene B, E3 ubiquitin protein ligase
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-12-18
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Ring finger proteins
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namevault RNA 2-1
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Synonyms gene
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Synonyms gene name
- microRNA 886
- vault RNA 2
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Synonyms
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Locus
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Discovery year2009-03-23
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Vault RNAs
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data