Rabbit Anti Human CBLC Antibody-Non-conjugated

• Catalog number
  CSB-PA892346ESR1HU_100ul
• Price
  Please ask
• Size
  100ul

• Long name
  Rabbit Antibody against Human CBLC, Non-conjugated
• Synonym name
  CBLC Human Antibody
• Species reactivity
  Human
• Tested applications recommended dilutions
  ELISA,IHC;Recommended dilution:IHC:1:20-1:200
• Conjugation
  Non-conjugated
• Antibody isotype
  IgG
• UniProt ID
  Q9ULV8
• Format
  Liquid, diluted in buffer
• Buffer composition
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Purity
  >95%
• Purification method
  Antigen Affinity Purified Antibodies
• Antibody category
  Polyclonal Antibodies
• Immunogen type
  Recombinant human E3 ubiquitin-protein ligase CBL-C protein (245-474AA)
• Immunogen species
  Human
• Alias
  RING finger protein 57,SH3-binding protein CBL-3,SH3-binding protein CBL-C,Signal transduction protein CBL-C,CBLC,CBL3,RNF57
• Background
  Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
• Clonality
  Polyclonal antibody
• Shipping and storage
  CBLC Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
• Properties
  If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• About
  Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus
• French translation
  anticorps

• Gene target
  CBLC   Non-conjugated  
• Gene symbol
  MMACHC, CBLC
• Short name
  Anti-CBLC
• Technique
  anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
• Host
  Rabbit, Rabbits
• Species
  Human, Humans
• Alternative name
  CBLC Antibody
• Alternative technique
  antibodies, rabbit-anti

Gene info

• Identity
  HGNC:24525
• Gene
  MMACHC
• Long gene name
  metabolism of cobalamin associated C
• Synonyms gene name
  • methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
• Synonyms
  • DKFZP564I122
  • cblC
• Locus
  1p34.1
• Discovery year
  2006-01-12
• Entrez gene record
  25974
• Pubmed identfication
  • 16311595
  • 19700356
  • 19801555
• RefSeq identity
  • NM_015506
• VEGA ID
  OTTHUMG00000007742
• Locus Specific Databases
  • MMACHC database at LOVD-China

Gene info

• Identity
  HGNC:15961
• Gene
  CBLC
• Long gene name
  Cbl proto-oncogene C
• Synonyms gene name
  • Cas-Br-M (murine) ectropic retroviral transforming sequence c
  • Cas-Br-M (murine) ecotropic retroviral transforming sequence c
  • Cbl proto-oncogene C, E3 ubiquitin protein ligase
• Synonyms
  • CBL-3
  • CBL-SL
  • RNF57
• GenBank acession
  • AB028645
• Locus
  19q13.32
• Discovery year
  2001-06-25
• Entrez gene record
  23624
• Pubmed identfication
  • 10362357
  • 10571044
• RefSeq identity
  • NM_012116
• Classification
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000150715
• Locus Specific Databases
  • LRG_1161

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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