GDC-0623

• Catalog number
  B1690-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  GDC-0623; GDC0623; GDC 0623; 5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
• Description
  GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM).
• CAS Number
  1168091-68-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₆H₁₄FIN₄O₃
• Molecular Weight
  456.21
• Cell Permeable
  Yes
• Purity
  >98%
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A MEK1 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  NA
• PubChem CID
  42642654
• PubChem CID Link
• SMILES
  C1=CC(=C(C=C1I)F)NC2=C(C=CC3=CN=CN32)C(=O)NOCCO
• InChi
  InChI=1S/C16H14FIN4O3/c17-13-7-10(18)1-4-14(13)20-15-12(16(24)21-25-6-5-23)3-2-11-8-19-9-22(11)15/h1-4,7-9,20,23H,5-6H2,(H,21,24)
• InChi Key
  RFWVETIZUQEJEF-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  GDC-0623  
• Short name
  GDC-0623
• Alternative name
  GDC-0623

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