GDC 0941, pan-PI3K kinase inhibitor
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Catalog numberSIH-501-25MG
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PricePlease ask
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Size25 mg
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Stock availabilitIn StockIn Stock
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CAS number957054-30-7
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Descriptionpan-PI3K kinase inhibitor
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Molecular weight513,63 g/mol
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Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other namePictrelisib, Pictilisib, GNE 0941, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC23H27N7O3S2
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OriginSynthetic
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Purity pourcentage≥98%
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Soluble inSoluble in DMSO
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Physical appearanceWhite solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number17755052
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Scientific contextGDC 0941 is a potent inhibitor of the PI 3-kinase family. Specifically, GDC 0941 has been shown to inhibit PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ.
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Bibliography1. Zheng J., Wang H., Yao J., & Zou X. (2014) Die Pharmazie. 69(1): 38–42.
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Release date1-Oct-2014
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of GDC 0941 (SIH-501), a pan-PI3K kinase inhibitor. CAS #: 957054-30-7. Molecular Formula: C23H27N7O3S2. Molecular Weight: 513.63 g/mol. Chemical structure of GDC 0941, a pan-PI3K kinase inhibitor (SIH-501). CAS # 957054-30-7. Molecular Formula: C23H27N7O3S2.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.025
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolPIK3C2B, PIK3CA, PIK3C2A, PIK3R5
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Short nameGDC 0941, pan-PI3K kinase inhibitor
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Alternative nameGDC 0941, pan-PI3K phosphorylation catalyst suppressor
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Gene info
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Identity
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Gene
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Long gene namephosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
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Synonyms gene name
- phosphoinositide-3-kinase, class 2, beta polypeptide
- phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-05-21
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Phosphatidylinositol 3-kinase subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namephosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
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Synonyms gene name
- phosphoinositide-3-kinase, catalytic, alpha polypeptide
- phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
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Synonyms
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Locus
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Discovery year1994-07-15
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Entrez gene record
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Pubmed identfication
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Classification
- Phosphatidylinositol 3-kinase subunits
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namephosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
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Synonyms gene name
- phosphoinositide-3-kinase, class 2, alpha polypeptide
- phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-05-21
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Phosphatidylinositol 3-kinase subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namephosphoinositide-3-kinase regulatory subunit 5
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Synonyms gene name
- phosphoinositide-3-kinase, regulatory subunit 5
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Synonyms
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GenBank acession
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Locus
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Discovery year2004-10-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID