GDC 0941,pan-PI3K kinase inhibitor

Research Area s

Cell Signaling , Cancer , Apoptosis , Cancer Growth Inhibitors , Tyrosine Kinase Inhibitors
Category

Small Molecules
Product Type

Inhibitor
CAS No

957054-30-7
MolecularFormula

C23H27N7O3S2
Molecular Weight

513.63
Purity

≥98%
Solubility

Soluble in DMSO
Appearance

White solid
Storage Temperature

-20°C
Shipping Temperature

Shipped Ambient
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Identity

HGNC:8972
Gene

PIK3C2B
Long gene name

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Synonyms gene name
- phosphoinositide-3-kinase, class 2, beta polypeptide
- phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Synonyms
- C2-PI3K
- PI3K-C2beta
GenBank acession
- Y11312
Locus

1q32.1
Discovery year

1998-05-21
Entrez gene record

5287
Pubmed identfication
- 9144573
- 9830063
RefSeq identity
- NM_002646
Classification
- Phosphatidylinositol 3-kinase subunits
VEGA ID

OTTHUMG00000036101

Identity

HGNC:8975
Gene

PIK3CA
Long gene name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Synonyms gene name
- phosphoinositide-3-kinase, catalytic, alpha polypeptide
- phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Synonyms
- PI3K
Locus

3q26.32
Discovery year

1994-07-15
Entrez gene record

5290
Pubmed identfication
- 1322797
Classification
- Phosphatidylinositol 3-kinase subunits
VEGA ID

OTTHUMG00000157311
Locus Specific Databases
- LRG_310

Identity

HGNC:8971
Gene

PIK3C2A
Long gene name

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms gene name
- phosphoinositide-3-kinase, class 2, alpha polypeptide
- phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Synonyms
- PI3K-C2alpha
GenBank acession
- Y13367
Locus

11p15.1
Discovery year

1998-05-21
Entrez gene record

5286
Pubmed identfication
- 9337861
RefSeq identity
- NM_002645
Classification
- Phosphatidylinositol 3-kinase subunits
VEGA ID

OTTHUMG00000166036